Characteristics of patients who had an IS at baseline grouped by LDL-C levels
| Variable | LDL-C categories | P value | |||||
| 1.80–2.59 (Reference) | <1.40 | 1.40–1.79 | 2.60–2.99 | 3.00–4.89 | ≥4.90 | ||
| N | 249 333 | 50 991 | 67 587 | 129 870 | 270 793 | 29 886 | – |
| Age, years | 66.60 (±12.01) | 67.38 (±12.23) | 67.48 (±12.07) | 65.99 (±11.89) | 65.30 (±11.84) | 65.20 (±12.02) | |
| Women (%) | 85 778 (34.40%) | 16 889 (33.12%) | 22 133 (32.75%) | 47 631 (36.68%) | 112 794 (41.65%) | 13 435 (44.95%) | <0.01 |
| NIHSS | 3 (2.6) | 3 (2.7) | 3 (2.6) | 3 (2.6) | 3 (2.6) | 4 (2.8) | <0.01 |
| Current Smoking, n (%) | 60 647 (24.32%) | 10 668 (20.92%) | 15 322 (22.67%) | 32 772 (25.23%) | 65 923 (24.11%) | 5500 (18.40%) | <0.01 |
| Alcohol intake, % | 59 613 (23.91%) | 11 745 (23.03%) | 15 922 (23.56%) | 31 268 (24.08%) | 62 197 (22.97%) | 6529 (21.85%) | <0.01 |
| Hypertension, % | 158 739 (63.67%) | 33 117 (64.95%) | 44 174 (65.36%) | 83 492 (64.29%) | 176 779 (65.28%) | 18 670 (62.47%) | <0.01 |
| Diabetes mellitus, % | 50 629 (20.31%) | 12 628 (24.77%) | 15 261 (22.58%) | 26 347 (20.29%) | 59 802 (22.08%) | 7171 (23.99%) | <0.01 |
| Dislipidemia, % | 15 600 (6.26%) | 3709 (7.27%) | 4753 (7.03%) | 8304 (6.39%) | 25 550 (9.44%) | 3897 (13.04%) | <0.01 |
| Previous atrial fib/flutter, % | 14 923 (5.99%) | 4371 (8.57%) | 5449 (8.06%) | 6031 (4.64%) | 10 086 (3.72%) | 1137 (3.80%) | <0.01 |
| Dual antiplatelet therapy, % | 97 860 (39.25%) | 17 697 (34.71%) | 25 393 (37.57%) | 53 069 (40.86%) | 109 214 (40.33%) | 9658 (32.32%) | <0.01 |
| Intravenous thrombolytic therapy, % | 15 135 (6.07%) | 3099 (6.08%) | 3861 (5.71%) | 8134 (6.26%) | 16 494 (6.09%) | 1452 (4.86%) | <0.01 |
| SBP, mm Hg | 148.76 (±22.55) | 144.93 (±22.59) | 146.56 (±22.24) | 150.73 (±22.84) | 152.52 (±23.22) | 151.28 (±24.14) | <0.01 |
| Body mass index, kg/m2 | 23.70 (±3.18) | 23.55 (±3.17) | 23.58 (±3.17) | 23.87 (±3.19) | 24.04 (±3.24) | 24.01 (±3.64) | <0.01 |
LDL-C, low-density lipoprotein cholesterol; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure.