Baseline characteristics
| Characteristics | IA thrombolytics (n=95) | No IA thrombolytics (n=2168) | P value |
| Age, median (IQR), years | 67 (56–76) | 71 (60–79) | 0.02 |
| Male, n (%) | 50/95 (53) | 1186/2168 (55) | 0.69 |
| Medical history, n (%) | |||
| Atrial fibrillation | 14/95 (14.7) | 491/2139 (23.0) | 0.06 |
| Diabetes mellitus | 10/95 (10.5) | 310/2153 (14.4) | 0.29 |
| Hypercholesterolemia | 23/95 (24.2) | 624/2067 (30.2) | 0.21 |
| Hypertension | 43/95 (45.3) | 1080/2126 (50.8) | 0.29 |
| Myocardial infarction | 12/95 (12.6) | 285/2129 (13.4) | 0.83 |
| Previous stroke | 8/95 (8.4) | 322/2150 (15.0) | 0.08 |
| Current smoker, n (%) | 26/70 (37.1) | 470/1664 (28.2) | 0.11 |
| Use of antiplatelet, n (%) | 26/95 (27.4) | 638/2138 (29.8) | 0.61 |
| Use of anticoagulation, n (%) | 8/95 (8.4) | 371/2151 (17.2) | 0.03 |
| Initial location occlusion on CTA, n (%) | |||
| Left hemisphere | 57/95 (60.0) | 1117/2168 (51.5) | 0.11 |
| Intracranial ICA | 30/95 (31.6) | 590/2164 (27.3) | 0.19 |
| M1 | 46/95 (48.4) | 1287/2164 (59.5) | |
| M2 | 19/95 (20.0) | 281/2164 (13.0) | |
| A1 | 0/95 (0) | 3/2164 (0.1) | |
| A2 | 0/95 (0) | 3/2164 (0.1) | |
| Collateral status, n (%) | |||
| Absent collaterals | 6/91 (6.6) | 136/2050 (6.6) | 0.68 |
| <50% of occluded area | 32/91 (35.2) | 752/2050 (36.7) | |
| 50%–99% of occluded area | 32/91 (35.2) | 791/2050 (38.6) | |
| 100% of occluded area | 21/91 (23.1) | 371/2050 (18.1) | |
| NIHSS score, median (IQR) | 15 (9–19) | 16 (11–19) | 0.24 |
| Intravenous thrombolysis, n (%) | 77/95 (81.1) | 1673/2163 (77.3) | 0.40 |
| Pre-intervention SBP, mean (SD), mm Hg | 152 (27) | 149 (25) | 0.26 |
A1, anterior cerebral artery, first segment; A2, anterior cerebral artery, second segment; CTA, computed tomography angiography; IA, intra-arterial; ICA, internal carotid artery; M1, middle cerebral artery, first segment; M2, middle cerebral artery, second segment; n, number; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure.