Table 4

Pooled ORs (95%CIs) in comprehensive evidence synthesis for the association between pregnancy/puerperium and brain arteriovenous malformation haemorrhage after adjustment

Grouping criterionIncluded studySample sizeRisk periodControl periodWeight, %RR
(95% CI)
Attributable risk per cent, %
EventAdjusted person-yearsEventAdjusted person-years
Female bAVM Patients IncludedFujita et al164234120129212.904.24 (1.42 to 12.71)
Bradley and Rose105855528245317.386.91 (2.96 to 16.14)
Porras et al9270915914010 66822.064.11 (2.14 to 7.89)
Zhu et al72648148214733620.851.82 (0.91 to 3.67)
Our study31117229305852326.802.02 (1.25 to 3.26)
Total (I2, 57.7%; pQ, 0.050; pZ<0.001)945100.003.15 (1.93 to 5.15)68.26
Female bAVM Patients from 15 to 45 years IncludedForster et al1519115187207340228.801.27 (0.77 to 2.11)
Liu et al123931240044111 76725.440.81 (0.46 to 1.42)
Tonetti et al17253218208006.334.13 (1.02 to 16.72)
van Beijnum et al18 Scotland44341416359.101.12 (0.36 to 3.49)
Our study18617126177213230.251.57 (0.97 to 2.55)
Total (I2, 33.3%; pQ, 0.200; pZ, 0.185)1067100.001.29 (0.89 to 1.86)22.24
  • pQ value for Q test; pZ value for Z test; the RR and 95% CI were calculated in random effects model.

  • RR, relative risks.