Pooled ORs (95%CIs) in comprehensive evidence synthesis for the association between pregnancy/puerperium and brain arteriovenous malformation haemorrhage after adjustment
| Grouping criterion | Included study | Sample size | Risk period | Control period | Weight, % | RR (95% CI) | Attributable risk per cent, % | ||
| Event | Adjusted person-years | Event | Adjusted person-years | ||||||
| Female bAVM Patients Included | Fujita et al16 | 42 | 3 | 41 | 20 | 1292 | 12.90 | 4.24 (1.42 to 12.71) | – |
| Bradley and Rose10 | 58 | 5 | 55 | 28 | 2453 | 17.38 | 6.91 (2.96 to 16.14) | – | |
| Porras et al9 | 270 | 9 | 159 | 140 | 10 668 | 22.06 | 4.11 (2.14 to 7.89) | – | |
| Zhu et al7 | 264 | 8 | 148 | 214 | 7336 | 20.85 | 1.82 (0.91 to 3.67) | – | |
| Our study | 311 | 17 | 229 | 305 | 8523 | 26.80 | 2.02 (1.25 to 3.26) | – | |
| Total (I2, 57.7%; pQ, 0.050; pZ<0.001) | 945 | – | – | – | – | 100.00 | 3.15 (1.93 to 5.15) | 68.26 | |
| Female bAVM Patients from 15 to 45 years Included | Forster et al15 | 191 | 15 | 187 | 207 | 3402 | 28.80 | 1.27 (0.77 to 2.11) | – |
| Liu et al12 | 393 | 12 | 400 | 441 | 11 767 | 25.44 | 0.81 (0.46 to 1.42) | – | |
| Tonetti et al17 | 253 | 2 | 18 | 20 | 800 | 6.33 | 4.13 (1.02 to 16.72) | – | |
| van Beijnum et al18 Scotland | 44 | 3 | 41 | 41 | 635 | 9.10 | 1.12 (0.36 to 3.49) | – | |
| Our study | 186 | 17 | 126 | 177 | 2132 | 30.25 | 1.57 (0.97 to 2.55) | – | |
| Total (I2, 33.3%; pQ, 0.200; pZ, 0.185) | 1067 | – | – | – | – | 100.00 | 1.29 (0.89 to 1.86) | 22.24 | |
pQ value for Q test; pZ value for Z test; the RR and 95% CI were calculated in random effects model.
RR, relative risks.