Table 2

Associations of parenchymal lesions with vascular pathology

	Lacunes in gross specimen† Median IQR (%), Wilcoxon p value			Microinfarcts† Median IQR (%), Wilcoxon p value			Myelin loss‡ β, p value		Haemosiderin‡ β, p value
	Lacunes in gross specimen† Median IQR (%), Wilcoxon p value			Microinfarcts† Median IQR (%), Wilcoxon p value			Myelin loss‡ β, p value		Perivascular		Parenchymal
	Present n=16	Absent n=9	P value	Present n=18	Absent n=9	P value	β	P value	β	P value	β	P value
Arteriolosclerosis (%)§ in brain regions
FPvWM	77.4, 50.9–84.4	64.3, 36.4–79.2	0.257	79.6, 62.5–85.7	61.9, 46.–76.5	0.091	−0.078	0.703	0.515	0.007	0.173	0.399
OPvWM	58.5, 22.0–76.7	52.9, 23.5–56.4	0.332	62.3, 23.5–75.9	53.6, 22.2–57.9	0.201	−0.036	0.862	0.220	0.281	0.020	0.921
DWM	42.7, 34.0–73.9	50.0, 25.0–55.3	0.558	52.6, 31.6–78.6	40.0, 33.3–50.0	0.184	−0.243	0.232	0.082	0.691	−0.214	0.295
SFC	56.4, 28.0–70.8	41.2, 19.2–60.0	0.292	59.2, 37.5–67.6	40.0, 19.2–66.7	0.337	–	–	0.182	0.373	−0.440	0.024*
OC	61.8, 26.9–81.7	16.7, 0–65.2	0.138	59.4, 13.6–78.3	42.8, 23.1–66.7	0.721	–	–	−0.059	0.773	0.097	0.638
Hippocampus	9.8, 0.0–59.2	10.5, 0–50.0	0.954	45.5, 0.0–60.0	8.3, 0.0–10.0	0.114	–	–	−0.232	0.253	−0.019	0.925
Putamen	59.2, 46.4–76.7	30.0, 24.1–40.9	0.004*	53.8, 31.8–68.4	50.0, 40.9–61.5	0.959	–	–	0.028	0.890	0.294	0.144
Venular collagenosis (%)** in brain regions
FPvWM	55.4, 36.7–70.0	64.7, 45.5–75.0	0.758	59.7, 46.3–70.0	45.5, 33.3–70.0	0.290	−0.344	0.086	0.054	0.792	0.008	0.971
OPvWM	66.7, 9.2–81.6	53.3, 10.7–66.7	0.373	66.7, 11.8–81.8	57.1, 10.7–75.0	0.683	−0.469	0.016*	0.136	0.507	−0.108	0.598
DWM	51.7, 8.8–69.7	40.0, 22.2–66.7	0.801	54.6, 40.0–70.6	18.2, 0–66.7	0.122	−0.437	0.025*	0.324	0.107	0.090	0.662
SFC	34.5, 28.2–57.7	41.7, 0–57.1	0.778	42.2, 25.5–57.1	35.7, 0–41.6	0.347	–	–	0.327	0.103	−0.167	0.415
OC	31.7, 2.6–67.1	38.1, 0–57.6	0.713	43.7, 0–63.6	33.3, 11.5–63.6	0.837	–	–	−0.096	0.642	−0.034	0.869
Hippocampus	4.1, 0.0–32.1	0.0, 0.0–31.3	0.928	26.5, 0–60.0	0.0, 0.0–0.0	0.036*	–	–	−0.081	0.695	−0.196	0.341
Putamen	34.5, 0.0–58.3	0.0, 0.0–53.8	0.454	33.3, 0–65.0	41.6, 0–53.8	0.855	–	–	−0.073	0.723	−0.256	0.206

*p<0.05.
†Associations with lacunes and microinfarcts were calculated using Wilcoxon signed-rank test (by defining microinfarct-mild/microinfarct-severe groups and lacunes/non-lacunes groups per region), and there was no significant difference in age at death between groups.
‡Associations with white matter pallor, perivascular haemosiderin leakage and parenchymal haemosiderin deposits were calculated using Spearman correlation test, adjusted for age.
§Arteriolosclerosis (%) = .
**Venular collagenosis (%) = .
DWM, deep white matter of parietal lobe; FPvWM, frontal periventricular white matter; OC, occipital cortex; OPvWM, occipital periventricular white matter; SFC, superior frontal cortex.