Table 2

Associations of parenchymal lesions with vascular pathology

Lacunes in gross specimen†
Median IQR (%), Wilcoxon p value
Microinfarcts†
Median IQR (%), Wilcoxon p value
Myelin loss‡
β, p value
Haemosiderin‡
β, p value
PerivascularParenchymal
Present n=16Absent n=9P valuePresent n=18Absent n=9P valueβP valueβP valueβP value
Arteriolosclerosis (%)§ in brain regions
FPvWM77.4, 50.9–84.464.3, 36.4–79.20.25779.6, 62.5–85.761.9, 46.–76.50.091−0.0780.7030.5150.0070.1730.399
OPvWM58.5, 22.0–76.752.9, 23.5–56.40.33262.3, 23.5–75.953.6, 22.2–57.90.201−0.0360.8620.2200.2810.0200.921
DWM42.7, 34.0–73.950.0, 25.0–55.30.55852.6, 31.6–78.640.0, 33.3–50.00.184−0.2430.2320.0820.691−0.2140.295
SFC56.4, 28.0–70.841.2, 19.2–60.00.29259.2, 37.5–67.640.0, 19.2–66.70.3370.1820.373−0.4400.024*
OC61.8, 26.9–81.716.7, 0–65.20.13859.4, 13.6–78.342.8, 23.1–66.70.721−0.0590.7730.0970.638
Hippocampus9.8, 0.0–59.210.5, 0–50.00.95445.5, 0.0–60.08.3, 0.0–10.00.114−0.2320.253−0.0190.925
Putamen59.2, 46.4–76.730.0, 24.1–40.90.004*53.8, 31.8–68.450.0, 40.9–61.50.9590.0280.8900.2940.144
Venular collagenosis (%)** in brain regions
FPvWM55.4, 36.7–70.064.7, 45.5–75.00.75859.7, 46.3–70.045.5, 33.3–70.00.290−0.3440.0860.0540.7920.0080.971
OPvWM66.7, 9.2–81.653.3, 10.7–66.70.37366.7, 11.8–81.857.1, 10.7–75.00.683−0.4690.016*0.1360.507−0.1080.598
DWM51.7, 8.8–69.740.0, 22.2–66.70.80154.6, 40.0–70.618.2, 0–66.70.122−0.4370.025*0.3240.1070.0900.662
SFC34.5, 28.2–57.741.7, 0–57.10.77842.2, 25.5–57.135.7, 0–41.60.3470.3270.103−0.1670.415
OC31.7, 2.6–67.138.1, 0–57.60.71343.7, 0–63.633.3, 11.5–63.60.837−0.0960.642−0.0340.869
Hippocampus4.1, 0.0–32.10.0, 0.0–31.30.92826.5, 0–60.00.0, 0.0–0.00.036*−0.0810.695−0.1960.341
Putamen34.5, 0.0–58.30.0, 0.0–53.80.45433.3, 0–65.041.6, 0–53.80.855−0.0730.723−0.2560.206
  • *p<0.05.

  • †Associations with lacunes and microinfarcts were calculated using Wilcoxon signed-rank test (by defining microinfarct-mild/microinfarct-severe groups and lacunes/non-lacunes groups per region), and there was no significant difference in age at death between groups.

  • ‡Associations with white matter pallor, perivascular haemosiderin leakage and parenchymal haemosiderin deposits were calculated using Spearman correlation test, adjusted for age.

  • §Arteriolosclerosis (%) = Embedded Image.

  • **Venular collagenosis (%) = Embedded Image.

  • DWM, deep white matter of parietal lobe; FPvWM, frontal periventricular white matter; OC, occipital cortex; OPvWM, occipital periventricular white matter; SFC, superior frontal cortex.