Secondary endpoints in EVT with and without CAS patients
| Endpoint | EVT with CAS (n=169) | EVT without CAS (n=264) | OR | 95% CI | aOR* | 95% CI |
| Successful intracranial reperfusion† | 101/164 (61.6) | 164/256 (64.1) | 0.91 | 0.60 to 1.36 | 0.73 | 0.43 to 1.23 |
| New clot in different vascular territory‡ | 14/154 (9.1) | 13/241 (5.4) | 1.81 | 0.84 to 3.92 | 2.96 | 1.07 to 8.21 |
| Symptomatic intracranial haemorrhage§ | 8/169 (4.7) | 20/264 (7.6) | 0.61 | 0.26 to 1.41 | 0.73 | 0.23 to 2.37 |
| Recurrent ischaemic stroke¶ | 3/169 (1.8) | 2/264 (0.8) | 2.37 | 0.39 to 14.32 | ** | |
| Any serious adverse event†† | 72/169 (42.6) | 99/264 (37.5) | 1.24 | 0.83 to 1.83 | 1.27 | 0.76 to 2.11 |
Data are presented as n (%). The data in this table are partly based on the data set before imputation (number of patients). For some variables, the denominators are smaller than the number of patients included due to missing data.
*Results were adjusted for age, sex, a medical history of atrial fibrillation, hypercholesterolaemia and myocardial infarction, smoking, antiplatelet use, coumarin use, National Institutes of Health Stroke Scale score at baseline, Alberta Stroke Programme Early CT Score, collateral score, intravenous thrombolysis, time from onset to recanalisation and percutaneous transluminal angioplasty during endovascular treatment.
†Successful intracranial reperfusion was defined as extended Thrombolysis In Cerebral Infarction score of ≥2B.
‡New clot in a different vascular territory was defined as a remaining proximal intracranial occlusion on last digital subtraction angiography run that did not match the thrombus locations scored on baseline CT angiography, and had changed either from one territory to another or from a distal occlusion location to a more proximal location.
§An intracranial haemorrhage was considered to be symptomatic if patients died or deteriorated neurologically (a decline of at least 4 points on the National Institutes of Health Stroke Scale) and the haemorrhage was related to the clinical deterioration (according to the Heidelberg criteria).
¶Recurrent ischaemic stroke was defined as a new ischaemic stroke that was confirmed on imaging, led to corresponding neurological deficits or resulted in death.
**The aOR could not be reliably determined due to the limited number of observations of recurrent ischaemic stroke.
††Any serious adverse event was defined as any untoward medical occurrence or effect causing mortality, a life-threatening situation, prolonged hospitalisation or persistent significant disability.
(a)OR, (adjusted) OR; CAS, carotid artery stenting; EVT, endovascular treatment.