Predictors of decline between 30 and 90 days
| Risk factor | OR (95% CI) Model 1* | OR (95% CI) Model 2† |
| NIHSS | 1.10 (0.96 to 1.27) | 1.17 (1.03 to 1.34) |
| Age (by year) | 1.02 (1.01 to 1.04) | 1.02 (1.00 to 1.03) |
| Stroke mechanism | ||
| Cardioembolism | Ref | Ref |
| Large artery atherosclerosis | 0.63 (0.35 to 1.14) | 0.75 (0.40 to 1.40) |
| Small artery occlusion | 0.46 (0.26 to 0.81) | 0.54 (0.30 to 0.99) |
| Other | 0.64 (0.39 to 1.05) | 0.77 (0.44 to 1.33) |
| Atrial fibrillation | 1.86 (1.13 to 3.06) | 1.36 (0.76 to 2.41) |
| Alteplase treatment | 0.55 (0.36 to 0.83) | 0.58 (0.37 to 0.90) |
Forty-six participants (3.4%) had an mRS 0–1 at 30 days but worsened to an mRS ≥3 at 90 days. This small group was older (mean age=74±12), with higher percentage of cardioembolic stroke (48%), atrial fibrillation (33%), anticoagulation therapy (12%), dyslipidaemia (70%), Medicare (74%), female (57%) and had a higher percentage of alteplase treatment (47%), p<0.05 in univariate analyses.
*Model 1: adjusted for NIHSS and age.
†Model 2: mutually adjusted for NIHSS, age, stroke mechanism, atrial fibrillation, alteplase treatment.
mRS, modified Rankin Scale; NIHSS, NIH Stroke Scale.