Table 3

The relationships between midline shift, cistern effacement, small vessel disease (old infarcts, van Swieten score) and measures of brain atrophy with MRS at day 90, death at day 4 and acute neurological deterioration

Variable	Day 90 mRS†		Day 4 death		Acute Neurological deterioration*
Variable	OR	P value	OR	P value	OR	Pvalue
Small vessel disease
Old infarcts (yes vs no)	1.11 (0.39 to 3.16)	0.84	1.80 (0.58 to 5.54)	0.30	0.94 (0.28 to 3.12)	0.91
Leukoaraiosis (per one point increase in van Swieten score)	0.84 (0.58 to 1.23)	0.37	1.23 (0.83 to 1.82)	0.29	1.16 (0.74 to 1.81)	0.52
Brain atrophy
Sylvian Fissure Ratio (per 1% increase)	1.06 (0.93 to 1.20)	0.42	0.97 (0.86 to 1.10)	0.68	1.07 (0.93 to 1.23)	0.36
Intercaudate distance (per mm increase)	1.02 (0.96 to 1.08)	0.53	1.03 (0.98 to 1.08)	0.28	1.01 (0.94 to 1.09)	0.72
Cerebral parenchymal volume/Intracranial volume (per 1% increase)	1.01 (0.97 to 1.05)	0.70	1.00 (0.96 to 1.05)	0.93	1.02 (0.97 to 1.08)	0.47

Comparisons by binary logistic regression shown as OR with 95% CIs, with adjustment for age, sex, GCS, systolic blood pressure, time from stroke onset to CT scan, treatment assignment (GTN vs no GTN) and haemorrhage volume.
*Acute neurological deterioration which was defined as an increase in National Institutes of Health Stroke Scale of ≥4 or a decrease in GCS of ≥2.25
†OR of mRS score >3.
CPV, cerebral parenchymal volume; GCS, Glasgow Coma Scale; GTN, glyceryl trinitrate; ICV, intracranial volume; mRS, modified Rankin scale; SFR, Sylvian fissure ratio.