The effects of baseline ICH volume (ICHV), ICH volume as a ratio of ICV (ICHV/ICV), ICH volume as a ratio of CPV (ICHV/CPV) (all measured by SAS), midline shift and cistern effacement on day 90 mRS, day 4 death and acute neurological deterioration
| Variable | Day 90 mRS† | Day 4 death | Acute neurological deterioration* | |||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| ICHV (per 10 mL) | 1.47 (1.14 to 1.88) | 0.003 | 1.15 (1.01 to 1.29) | 0.031 | 1.20 (1.01 to 1.42) | 0.036 |
| ICHV/ICV (per 1% increase) | 1.79 (1.24 to 2.59) | 0.002 | 1.24 (1.06 to 1.47) | 0.009 | 1.40 (1.11 to 1.78) | 0.005 |
| ICHV/CPV (per 1% increase) | 1.63 (1.20 to 2.21) | 0.006 | 1.21 (1.06 to 1.37) | 0.005 | 1.33 (1.09 to 1.62) | 0.005 |
| Midline shift (per mm increase) | 1.46 (1.11 to 1.93) | 0.007 | 1.17 (1.04 to 1.31) | 0.009 | 1.36 (1.06 to 1.73) | 0.014 |
| Cistern effacement (per one point increase from total of 4) | 1.76 (1.01 to 3.09) | 0.048 | 2.28 (1.53 to 3.41) | <0.001 | 2.03 (1.10 to 3.76) | 0.024 |
Comparisons by binary logistic regression shown as OR with 95% CIs, with adjustment for age, sex, GCS, systolic blood pressure, time from stroke onset to CT scan, treatment assignment (GTN vs no GTN).
*Acute neurological deterioration which was defined as an increase in National Institutes of Health Stroke Scale of ≥4 or a decrease in GCS of ≥2.25
†OR of mRS score >3
CPV, cerebral parenchymal volume; GCS, Glasgow Coma Scale; GTN, glyceryl trinitrate; ICHV, ICH volume; ICV, intracranial volume; mRS, modified Rankin scale.