Variable | N | All | SVD | Score | P value |
Low | Moderate-severe | ||||
Patients randomised | 363 | 99 | 264 | ||
Scan | |||||
Scan type (%) | |||||
CT | 363 | 320 (88.2) | 90 (90.9) | 230 (87.1) | 0.32 |
Time to CT (days) | 320 | 1.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 1.0 (0.0, 1.0) | 0.19 |
MRI | 362 | 263 (72.5) | 60 (60.6) | 203 (76.9) | 0.0020 |
Time to MRI (days) | 263 | 3.0 (1.0, 9.0) | 2.0 (1.0, 5.0) | 3.0 (1.0, 11.0) | 0.097 |
Scan quality (%) | 0.28 | ||||
Good | 237 (65.3) | 66 (66.7) | 171 (64.8) | ||
Moderate | 118 (32.5) | 29 (29.3) | 89 (33.7) | ||
Poor | 8 (2.2) | 4 (4.0) | 4 (1.5) | ||
Index lesion (%) | |||||
Normal scan | 1 (0.3) | 1 (1.0) | 0 (0.0) | 1.00 | |
Lesion present (type) | 0.0006 | ||||
Primary infarct | 319 (87.9) | 77 (77.8) | 242 (91.7) | ||
Primary haemorrhage | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
Mimic | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
No acute lesion visible | 43 (11.8) | 21 (21.2) | 22 (8.3) | ||
Infarct side of brain | 320 | 0.22 | |||
Right | 142 (44.4) | 29 (37.7) | 113 (46.5) | ||
Left | 175 (54.7) | 48 (62.3) | 127 (52.3) | ||
Both | 3 (0.9) | 0 (0.0) | 3 (1.2) | ||
Location (%) | 320 | ||||
Small subcortical infarct | 311 (97.2) | 72 (93.5) | 239 (98.4) | 0.33 | |
Internal capsule | 110 (34.4) | 21 (27.3) | 89 (36.6) | ||
External capsule | 4 (1.3) | 1 (1.3) | 3 (1.2) | ||
Lentiform nucleus | 31 (9.7) | 7 (9.1) | 24 (9.9) | ||
Internal border zone | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
Centrum semiovale | 83 (25.9) | 23 (29.9) | 60 (24.7) | ||
Thalamus | 64 (20.0) | 17 (22.1) | 47 (19.3) | ||
Cerebellum | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
Brainstem lesion (pons) | 18 (5.6) | 3 (3.9) | 15 (6.2) | ||
Medulla | 1 (0.3) | 0 (0.0) | 1 (0.4) | ||
Non-small subcortical infarct | |||||
MCA territory | 320 | 9 (2.8) | 4 (5.2) | 5 (2.1) | 0.23 |
PCA territory | 320 | 2 (0.6) | 1 (1.3) | 1 (0.4) | 0.42 |
Infarct size (mm) | 320 | ||||
A/P | 10.0 (8.0, 12.0) | 10.0 (8.0, 12.0) | 10.0 (8.0, 12.0) | 0.97 | |
R/L | 9.0 (6.0, 11.0) | 9.0 (6.0, 10.0) | 9.0 (6.0, 11.0) | 0.91 | |
Cranio-caudal | 10.0 (8.0, 15.0) | 10.0 (8.0, 12.0) | 10.0 (8.0, 15.0) | 0.15 |
Data are number (%), median (IQR) or mean (SD). The number of participants with data is 363 unless stated.
Index lesion=main cause of stroke symptoms.
Index small subcortical infarct=acute lacunar.
Non-small subcortical infarct=large artery cortical or large subcortical or posterior circulation.
SVD, small vessel disease.