Associations between CHIP and different outcomes in patients who had a first-ever AIS
| CHIP n=220 | No CHIP n=5796 | Unadjusted | Model 1* | Model 2† | Model 3‡ | |||||
| n, (%) | n, (%) | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Stroke | 14 (6.4) | 343 (5.9) | 1.08 (0.63 to 1.84) | 0.79 | 1.56 (0.997 to 2.44) | 0.052 | 1.62 (1.04 to 2.51) | 0.03 | 1.56 (0.997 to 2.44) | 0.052 |
| IS | 13 (5.9) | 320 (5.5) | 1.07 (0.62 to 1.87) | 0.80 | 1.59 (1.00 to 2.51) | 0.048 | 1.64 (1.04 to 2.58) | 0.03 | 1.59 (1.00 to 2.52) | 0.048 |
| Comb | 14 (6.4) | 353 (6.1) | 1.05 (0.61 to 1.79) | 0.86 | 1.52 (0.97 to 2.37) | 0.07 | 1.58 (1.02 to 2.44) | 0.04 | 1.52 (0.97 to 2.37) | 0.07 |
| Death | 3 (1.4) | 69 (1.2) | 1.15 (0.36 to 3.66) | 0.81 | 0.69 (0.16 to 2.97) | 0.62 | 1.11 (0.35 to 3.56) | 0.86 | 0.69 (0.16 to 2.97) | 0.62 |
Data were adjusted with a stable inverse probability of treatment weighting based on the propensity score (PS).
*In model 1, variables used for calculating PS included age, sex, body mass index, smoking, drinking, history of the disease (ie, hypertension, diabetes mellitus and hyperlipidaemia), Trial of Org 10 172 in Acute Stroke Treatment classification, and National Institutes of Health Stroke Scale Score.
†In model 2, the variables used for calculating PS include variables in model 1 and high-sensitivity C reactive protein levels at baseline.
‡In model 3, the variables used for calculating PS include variables in model 1 and the severity of intracranial artery stenosis.
AIS, acute ischaemic stroke; CHIP, clonal haematopoiesis of indeterminate potential; Comb, combined vascular event; IS, ischaemic stroke.