Comparison of nomograms in risk reclassification
| Nomograms | Continuous NRI, % | Categorical NRI, % | IDI, % | |||
| Estimate (95% CI) | P value | Estimate (95% CI) | P value | Estimate (95% CI) | P value | |
| Comparison 1 | ||||||
| Nomogram I: conventional vascular risk factors only* | Ref. | <0.001 | Ref. | 0.015 | Ref. | 0.009 |
| Nomogram III: the D2H2A nomogram† | 70.89 (30.84 to 110.94) | 25.11 (4.83 to 45.39) | 5.18 (1.29 to 9.08) | |||
| Comparison 2 | ||||||
| Nomogram II: conventional vascular risk factors* + severity of luminal stenosis in sICAS | Ref. | <0.001 | Ref. | 0.015 | Ref. | 0.014 |
| Nomogram III: the D2H2A nomogram† | 71.56 (29.52 to 113.59) | 25.11 (4.83 to 45.39) | 4.73 (0.96 to 8.5) | |||
*Conventional vascular risk factors included age ≥50 years, diabetes, dyslipidaemia and hypertension.
†The D2H2A nomogram incorporated diabetes, dyslipidaemia, haemodynamic status of sICAS, hypertension and age ≥50 years.
IDI, integrated discrimination improvement; NRI, net reclassification improvement; sICAS, symptomatic intracranial atherosclerotic stenosis.