Clinical outcome comparison between the ACO and PCO groups with different time windows
| ACO | PCO | Multivariable logistic regression | |||||||||
| Unadjusted | Adjusted 1* | Adjusted 2# | |||||||||
| OR (95% CI) | P value | P value for interaction | aOR (95% CI) | P value | P value for interaction | aOR (95% CI) | P value | P value for interaction | |||
| Any ICH within 24 hours* | |||||||||||
| OPT | |||||||||||
| ≤6 hours | 246 (28.34%) | 40 (16.19%) | 0.489 (0.338 to 0.707) | 0.0001 | 0.8034 | 0.510 (0.352 to 0.739) | 0.0004 | 0.8229 | 0.706 (0.412 to 1.209) | 0.2041 | 0.1524 |
| >6 hours | 153 (29.77%) | 27 (18.24%) | 0.526 (0.333 to 0.832) | 0.0060 | 0.539 (0.340 to 0.854) | 0.0085 | 0.481 (0.250 to 0.926) | 0.0285 | |||
| Symptomatic ICH within 24 hours† | |||||||||||
| OPT | |||||||||||
| ≤6 hours | 77 (9.45%) | 3 (1.32%) | 0.128 (0.040 to 0.409) | 0.0005 | 0.0115 | 0.140 (0.044 to 0.449) | 0.0009 | 0.0118 | 0.249 (0.066 to 0.943) | 0.0406 | 0.2331 |
| >6 hours | 40 (8.06%) | 9 (6.25%) | 0.760 (0.360 to 1.606) | 0.4724 | 0.763 (0.359 to 1.618) | 0.4801 | 0.609 (0.200 to 1.858) | 0.3839 | |||
| mRS 0–2 at 90 days‡ | |||||||||||
| OPT | |||||||||||
| ≤6 hours | 353 (43.05%) | 118 (50.21%) | 1.334 (0.998 to 1.784) | 0.0518 | 0.0004 | 1.266 (0.941 to 1.703) | 0.1189 | 0.0004 | 1.812 (1.145 to 2.868) | 0.0112 | 0.0038 |
| >6 hours | 246 (48.91%) | 50 (34.97%) | 0.562 (0.382 to 0.826) | 0.0034 | 0.514 (0.346 to 0.763) | 0.0010 | 0.938 (0.532 to 1.655) | 0.8262 | |||
| mRS 0–3 at 90 days§ | |||||||||||
| OPT | |||||||||||
| ≤6 hours | 447 (54.51%) | 136 (57.87%) | 1.146 (0.855 to 1.537) | 0.3613 | <0.0001 | 1.077 (0.798 to 1.453) | 0.6286 | <0.0001 | 1.360 (0.857 to 2.158) | 0.1920 | 0.0025 |
| >6 hours | 300 (77.86%) | 56 (39.16%) | 0.436 (0.298 to 0.637) | <0.0001 | 0.398 (0.269 to 0.590) | <0.0001 | 0.717 (0.408 to 1.259) | 0.2468 | |||
| Mortality at 90 days¶ | |||||||||||
| OPT | |||||||||||
| ≤6 hours | 135 (16.46%) | 36 (15.32%) | 0.918 (0.615 to 1.370) | 0.6748 | <0.0001 | 0.979 (0.653 to 1.467) | 0.9181 | <0.0001 | 0.690 (0.363 to 1.314) | 0.2590 | 0.0002 |
| >6 hours | 56 (11.13%) | 44 (30.77%) | 3.548 (2.260 to 5.569) | <0.0001 | 3.829 (2.409 to 6.085) | <0.0001 | 2.673 (1.280 to 5.583) | 0.0089 | |||
Adjusted 1* Adjust age and gender.
Adjusted 2# Adjust all confounding factors in multivariable analysis.
*Adjust PRT, hypertension, extra angioplasty, ASTIN/SIR grade, general anaesthesia.
†Adjust SBP, hypercholesterolaemia, general anaesthesia, ASTIN/SIR grade, intracranial atherosclerotic disease.
‡Adjust general anaesthesia, admission NIHSS.
§Adjust general anaesthesia, extra angioplasty, admission NIHSS.
¶Adjust smoke, general anaesthesia, admission NIHSS.
ACO, anterior circulation artery occlusion; aOR, adjusted OR; ASTIN/SIR, American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology; ICH, intracranial haemorrhage; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; OPT, onset to puncture time; PCO, posterior circulation artery occlusion; SBP, systolic blood pressure.