Multivariable logistic regression models predicting an abnormal TTE finding (left), a Category I finding (left-centre), a Category II finding (right-centre) and a Category III finding (right) among those with no prestroke history of heart failure
Covariates | TTE abnormality n=4157 OR (95% CI) | P value | Model c-statistic | Category I abnormality n=981 OR (95% CI) | P value | Model c-statistic | Category II abnormality n=1519 OR (95% CI) | P value | Model c-statistic | Category III abnormality n=3535 OR (95% CI) | P value | Model c- statistic |
Older age | 2.01 (1.73 to 2.34) | <0.001 | 0.71 | 0.53 (0.45 to 0.62) | <0.001 | 0.68 | 1.74 (1.50 to 2.01) | <0.001 | 0.73 | 2.83 (2.48 to 3.24) | <0.001 | 0.75 |
Male gender | 1.22 (1.07 to 1.39) | 0.004 | ||||||||||
Caucasian | 1.36 (1.10 to 1.70) | 0.005 | ||||||||||
Coronary artery disease/prior MI | 3.44 (2.64 to 4.47) | <0.001 | 3.73 (3.21 to 4.34) | <0.001 | 2.02 (1.66 to 2.45) | <0.001 | ||||||
Atrial fibrillation | 3.15 (2.40 to 4.14) | <0.001 | 0.61 (0.48 to 0.77) | <0.001 | 1.75 (1.49 to 2.05) | <0.001 | 3.41 (2.71 to 4.29) | <0.001 | ||||
Prior antihypertensive medication | 1.32 (1.14 to 1.54) | <0.001 | 0.67 (0.57 to 0.79) | <0.001 | 1.22 (1.05 to 1.42) | 0.009 | 1.84 (1.60 to 2.11) | <0.001 | ||||
Diabetes mellitus | 1.28 (1.06 to 1.54) | 0.010 | 0.76 (0.63 to 0.93) | 0.007 | 1.45 (1.23 to 1.71) | <0.001 | ||||||
Chronic kidney disease | 1.62 (1.02 to 2.58) | 0.041 | ||||||||||
Prior antiplatelet use | 0.74 (0.62 to 0.89) | 0.002 | ||||||||||
Admission NIHSS ≥4 | 0.63 (0.54 to 0.73) | <0.001 | 1.44 (1.26 to 1.65) | <0.001 | 1.17 (1.03 to 1.33) | 0.017 | ||||||
Cortical infarct | 1.38 (1.18 to 1.61) | <0.001 | ||||||||||
Infratentorial infarct | 0.81 (0.68 to 0.96) | 0.0139 | ||||||||||
Patent intracranial and extracranial arteries | 1.18 (1.01 to 1.38) | 0.043 | 1.50 (1.26 to 1.78) | <0.001 | 1.29 (1.12 to 1.49) | <0.001 |
MI, myocardial infarction; NIHSS, National Institutes of Health Stroke Scale; TTE, transthoracic echocardiography.