Baseline characteristics
| Characteristic | ACO (n=1396) | PCO (n=397) | P value |
| Age (years) | 66(56–73) | 64(55–72) | 0.0038 |
| Male (n,%) | 878 (62.89%) | 301 (75.82%) | <0.0001 |
| BMI | 24.42±3.63 | 24.79±3.70 | 0.0479 |
| Hypertension (n,%) | 757 (54.23%) | 272 (68.51%) | <0.0001 |
| Hypercholesterolaemia (n,%) | 109 (7.81%) | 50 (12.59) | 0.0031 |
| Diabetes mellitus (n,%) | 246 (17.62%) | 86 (21.66%) | 0.0674 |
| CAD (n,%) | 212 (15.19%) | 63 (15.87%) | 0.7390 |
| Current smoker (n,%) | 408 (29.23%) | 140 (35.26%) | 0.0212 |
| Atrial fibrillation (n,%) | 572 (40.97%) | 78 (19.65%) | <0.0001 |
| History of stroke (n,%) | 257 (18.41%) | 89 (22.42%) | 0.0741 |
| History of TIA (n,%) | 31 (2.22%) | 22 (5.54%) | 0.0006 |
| Admission NIHSS | 16(12–20) | 22 (11–35) | <0.0001 |
| ASPECTS/pc-ASPECTS | 9 (7–10) | 9 (7–10) | |
| SBP, mm Hg | 145(130–160) | 150(138–166) | <0.0001 |
| IV thrombolysis (n,%) | 416 (29.80%) | 108 (27.20%) | 0.3157 |
| Onset to thrombolysis, min | 166 (120–180) | 173 (120–180) | 0.0410 |
| General anaesthesia (n,%) | 502 (35.96%) | 221 (55.67%) | <0.0001 |
| ASTIN/SIR 3–4 (n,%) | 522 (37.39%) | 173 (43.58%) | 0.0256 |
| Underlying ICAD (n,%)* | 359 (29.47%) | 175 (51.47%) | <0.0001 |
| Tandem occlusion (n,%) | 305 (21.85%) | 74 (18.64%) | 0.1671 |
| IA thrombolysis(n,%) | 99 (7.09%) | 50 (12.59%) | 0.0005 |
| Mechanical thrombectomy (n,%) | 1269 (90.9%) | 338 (85.14%) | 0.0009 |
| Number of thrombectomy | 2 (1–3) | 1 (1–2) | <0.0001 |
| Heparin during MT (n,%) | 669 (47.92%) | 205 (51.64%) | 0.1914 |
| IIb/IIIa inhibitor (n,%) | 677 (48.50%) | 250 (62.97%) | <0.0001 |
| Extra angioplasty (n,%) | 365 (26.15%) | 160 (40.30%) | <0.0001 |
| Permanent stenting (n,%) | 212 (15.19%) | 113 (28.46%) | <0.0001 |
| Onset to puncture, min | 300 (210–440) | 298 (208–428) | 0.2664 |
| Onset to recanalisation, min | 404 (300–555) | 481.5 (360–765) | <0.0001 |
| Puncture to recanalisation, min | 83 (51–128) | 93 (59–139) | 0.0088 |
| Stoke subtype by TOAST criteria† | |||
| Large artery atherosclerosis (n,%) | 634 (48.40%) | 257 (67.99%) | <0.0001 |
| Cardioembolism (n,%) | 517 (39.47%) | 70 (18.52%) | |
| Other or unknown aetiology (n,%) | 159 (12.14%) | 51 (13.49%) | |
*Missing 235 data.
†Missing 105 data.
ACO, anterior circulation artery occlusion; ASPECTS, Alberta Stroke Programme Early CT Score; ASTIN/SIR, American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology Collateral Flow Grading System; BMI, body mass index; CAD, coronary artery disease; IA, intra-artery; ICAD, intracranial atherosclerotic disease; IV, intravenous; MT, mechanical thrombectomy; NIHSS, National Institute of Health Stroke Scale; pc-ASPECTS, posterior circulation Acute Stroke Prognosis Early CT Score; PCO, posterior circulation artery occlusion; SBP, systolic blood pressure; TIA, transient ischaemic attack; TOAST, Trial of Org 10 172 in Acute Stroke Treatment.