Performance of clinical and CT features in predicting NOTCH3 p.R544C mutation
| aOR (95% CI)* | AUC-ROC (95% CI) | P value † | |
| Total WML score | 0.79 (0.37 to 1.66) | 0.69 (0.52 to 0.86) | 0.047 |
| External capsule WML | 1.70 (0.39 to 7.33) | 0.67 (0.53 to 0.82) | 0.141 |
| Prominent lobar lacune | 2.32 (0.53 to 10.13) | 0.57 (0.45 to 0.69) | 0.038 |
| Prominent juxtacortical WML | 20.4 (1.54 to 271.0) | 0.76 (0.63 to 0.90) | – |
Numbers in bold indicating statistical significance (P<0.05).
*Simultaneously adjusted with these three imaging markers.
†Compared with prominent juxtacortical WML alone.
aOR, adjusted OR; AUC-ROC, area under the receive operating characteristic curve; WML, white matter lesion.