CT features distinguishing patients with ICH with and without NOTCH3 p.R544C mutation
| NOTCH3 mutation (−), n=286 | NOTCH3 mutation (+), n=13 | P value | Unadjusted OR (95% CI) | Demographic-adjusted OR (95% CI)* | |
| Anterior WML score | 0.9±0.8 | 1.4±0.9 | 0.03 | 2.23 (1.05 to 4.74) | 2.84 (1.22 to 6.60) |
| Posterior WML score | 0.7±0.8 | 1.4±0.9 | 0.01 | 2.44 (1.24 to 4.81) | 3.56 (1.60 to 7.91) |
| Total WML score | 1.6±1.5 | 2.8±1.7 | 0.02 | 1.61 (1.11 to 2.35) | 1.99 (1.27 to 3.12) |
| Prominent juxtacortical WML | 47 (16.4%) | 9 (69.2%) | <0.001 | 10.6 (3.31 to 34.3) | 20.9 (4.94 to 88.6) |
| Pattern 1 | 26 (55.3%) | 4 (44.4%) | 0.72 | ||
| Pattern 2 | 21 (44.7%) | 5 (55.6%) | |||
| Anterior temporal lobe WML | 1 (0.35%) | 0 (0%) | 0.83 | NA | NA |
| External capsule WML | 33 (11.5%) | 6 (46.2%) | <0.001 | 6.56 (2.14 to 20.1) | 8.28 (2.27 to 30.2) |
| Cortical atrophy score | 0.7±0.7 | 1.0±0.8 | 0.24 | 1.56 (0.77 to 3.17) | 1.85 (0.69 to 4.96) |
| Central atrophy score | 0.9±0.8 | 1.2±1.0 | 0.25 | 1.51 (0.79 to 2.91) | 1.75 (0.74 to 4.14) |
| Total atrophy score | 1.6±1.5 | 2.2±1.7 | 0.23 | 1.28 (0.89 to 1.83) | 1.44 (0.87 to 2.41) |
| Presence of lacune | 125 (43.7%) | 8 (61.5%) | 0.26 | 1.99 (0.66 to 5.98) | 2.15 (0.72 to 6.42) |
| Number of lacune | 1.2±1.9 | 1.9±2.1 | 0.13 | 1.18 (0.95 to 1.47) | 1.21 (0.96 to 1.51) |
| Prominent lobar lacune | 25 (8.7%) | 3 (23.1%) | 0.11 | 3.42 (0.94 to 12.5) | 3.91 (1.03 to 14.8) |
Numbers in bold indicating statistical significance (P<0.05).
*Adjusted by age, sex and hyperlipidaemia.
WML, white matter lesion.