Clinical characteristics between patients with ICH with and without NOTCH3 p.R544C mutation
| NOTCH3 mutation (−) n=286 | NOTCH3 mutation (+) n=13 | P value | |
| Age | 61.3±14.7 | 64.2±12.1 | 0.44 |
| Male sex | 194 (67.8%) | 8 (61.5%) | 0.64 |
| Medical history | |||
| Hypertension | 263 (92.0%) | 11 (84.6%) | 0.30 |
| Diabetes mellitus | 88 (31.0%) | 5 (38.5%) | 0.55 |
| Hyperlipidaemia | 89 (31.1%) | 9 (69.2%) | 0.004 |
| Smoking | 104 (36.6%) | 3 (23.1%) | 0.39 |
| Heart disease | 68 (23.9%) | 1 (7.7%) | 0.31 |
| Previous ischaemic stroke | 29 (10.1%) | 2 (15.4%) | 0.65 |
| Previous ICH | 27 (9.4%) | 3 (23.1%) | 0.16 |
| Parental stroke | 72 (25.4%) | 4 (30.8%) | 0.75 |
| Sibling stroke | 37 (13.1%) | 4 (30.8%) | 0.09 |
| ICH location | 0.39 | ||
| Thalamus | 77 (26.9%) | 6 (46.2%) | |
| Basal ganglia | 106 (37.1%) | 3 (23.1%) | |
| Cortical-subcortical | 55 (19.2%) | 1 (7.7%) | |
| Infratentorium | 46 (16.1%) | 3 (23.1%) | |
| Multiple or others | 2 (1.0%) | 0 (0%) | |
| ICH size, mL | 14.2±17.9 | 13.4±17.6 | 0.30 |
| IVH | 90 (31.7%) | 4 (30.8%) | 0.99 |
| Admission status | |||
| Glasgow coma scale | 12.6±3.5 | 13.0±3.2 | 0.58 |
| Systolic blood pressure | 182.7±37.8 | 185.0±29.9 | 0.76 |
| Diastolic blood pressure | 101.7±25.0 | 100.5±14.2 | 0.96 |
| Heart rate | 86.3±17.8 | 86.0±23.2 | 0.36 |
| NIHSS | 13.0±9.5 | 13.1±11.5 | 0.77 |
| ICH score | 1.2±1.2 | 1.2±1.1 | 0.96 |
| Discharge status | |||
| Length of stay, days | 15.5±14.4 | 10.9±5.7 | 0.48 |
| NIHSS at discharge | 10.1±11.6 | 13.8±14.0 | 0.37 |
| Change of NIHSS | −3.3±8.3 | 0.7±7.1 | 0.02 |
| Barthel index | 59.6±36.8 | 39.2±44.9 | 0.13 |
| Modified Rankin scale | 2.9±1.6 | 3.5±1.9 | 0.20 |
Numbers in bold indicating statistical significance (P<0.05).
ICH, intracerebral haemorrhage; IVH, intraventricular haemorrhage; NIHSS, National Institute of Health Stroke Scale.