Variable (reference units) | d1* | d2* | d3* | d4* | d5* | d6* | d7* | d8* | d9* | d10* | d18† |
Patient 1 (39 years, first ChAdOx1 nCov-19 vaccination 8 days before hospital admission) | CSVT | ||||||||||
Platelets (140–440×109/L) | 84 | 61 | 51 | 36 | 47 | 67 | 104 | 104 | 98 | 121 | 126 |
D-dimer (0.5 mg/L) | 14.2 | 11.4 | 11.8 | 11.9 | 14.4 | 9.36 | 8.63 | 7.1 | 7.65 | 4.14 | 0.91 |
Fibrinogen (210–400 mg/dL) | 236 | 234 | 173 | 143 | 83 | 62 | 64 | 90 | 201 | 292 | 285 |
Coagulation factor 13 (>70%) | 119 | 117 | – | 94 | 77 | 67 | – | 68 | 65 | – | 99 |
CRP (<5.0 mg/L) | 1.3 | 2.9 | 0.7 | <0.6 | <0.6 | <0.6 | <0.6 | <0.6 | – | 6.2 | – |
Ferritin (9–140 ng/mL) | 83 | – | 100 | 78 | 68 | 63 | – | – | – | – | – |
Interleukin 6 (0–7.0 pg/mL) | 12 | – | 4 | 3.6 | 3.6 | 4.2 | – | – | – | – | – |
Patient 2 (24 years, first ChAdOx1 nCov-19 vaccination 12 days before hospital admission) | CSVT | ||||||||||
Platelets (140–440×109/L) | 29 | 41 | 78 | 135 | 166 | 188 | 258 | 304 | 337 | 254 | 183 |
D-dimer (0.5 mg/L) | >33 | 23.6 | 14.6 | 2.81 | 1.81 | 1.53 | 2.91 | 2.81 | 3.31 | 2.25 | 1.35 |
Fibrinogen (210–400 mg/dL) | 95 | 55 | <50 | <50 | <50 | <50 | 152 | 169 | 208 | 232 | 254 |
Coagulation factor 13 (>70%) | – | 25 | – | 36 | 22 | – | – | – | 46 | 58 | 98 |
CRP (<5.0 mg/L) | 16.7 | 14.2 | 9.4 | 3.7 | 2.6 | 1.7 | 1.3 | 3.9 | 3.1 | 1.3 | 1.5 |
Ferritin (9–140 ng/mL) | 80 | – | – | 61 | 47 | – | – | – | – | – | – |
Interleukin 6 (0–7.0 pg/mL) | 11 | – | – | 2.7 | 2.5 | – | – | – | – | – | – |
*Hospital treatment
†Follow-up visit 1 week after hospital discharge
CRP, C reactive protein; CSVT, cerebral sinus venous thrombosis (diagnosis); d, day.