Baseline characteristics
| Variable | r-tPA (N=2666) | UK (N=1144) | P value |
| Dose, mg/U per kg | 0.88 (0.78–0.90) | 1.71 (1.43–2.00)×104 | – |
| Age, years | 63.8 (11.5) | 63.5 (63.8) | 0.399 |
| Male | 1827 (68.5) | 779 (68.1) | 0.791 |
| BMI, kg/m2 | 24.1 (3.8) | 24.2 (3.4) | 0.490 |
| Educational level | 0.006 | ||
| Primary school degree or below | 762 (28.6) | 370 (32.3) | |
| Middle school degree | 1623 (60.9) | 685 (59.5) | |
| Bachelor degree or above | 281 (10.5) | 89 (7.8) | |
| Current smoker | 1006 (37.7) | 442 (38.6) | 0.599 |
| Current drinker | 607 (22.8) | 279 (24.4) | 0.278 |
| Hypertension | 1435/2599 (55.2) | 599/1097 (54.6) | 0.733 |
| Coronary heart disease | 394/2549 (15.5) | 167/1069 (15.6) | 0.900 |
| History of stroke | 532/2573 (20.7) | 263/1089 (22.6) | 0.020 |
| Diabetes mellitus | 507/2600 (19.5) | 209/1092 (19.1) | 0.800 |
| Atrial fibrillation | 254/2547 (10.0) | 93/1064 (8.7) | 0.252 |
| SBP, mm Hg | 151.2 (22.8) | 153.3 (23.7) | 0.009 |
| OTT, min | 170 (128–210) | 190 (142–234) | <0.001 |
| DNT, min | 30 (14–55) | 35 (18–61) | <0.001 |
| NIHSS score | 6.0 (3.0–10.0) | 5.0 (3.0–9.0) | 0.010 |
| TOAST classification | 0.639 | ||
| LAA | 1297 (49.4) | 538 (47.7) | |
| CE | 304 (11.6) | 124 (11.0) | |
| SAO | 814 (31.0) | 378 (33.5) | |
| ODC | 63 (2.4) | 24 (2.1) | |
| UND | 149 (5.7) | 65 (5.8) | |
| Hospital classification | 0.417 | ||
| Tertiary | 2418 (90.7) | 1047 (91.5) | |
| Secondary | 248 (9.3) | 97 (8.5) |
Data are n/N (%), mean (SD) or median (IQR).
BMI, body mass index; CE, cardioembolism; DNT, door-to-needle time; LAA, large-artery atherosclerosis; NIHSS, National Institutes of Health Stroke Scale; ODC, stroke of other determined cause; OTT, onset-to-treatment time; r-tPA, recombinant tissue plasminogen activator; SAO, small-artery occlusion; SBP, systolic blood pressure; TOAST, Trial of Org 10172 in Acute Stroke Treatment; UK, urokinase; UND, stroke of undetermined cause.