Table 3

Association between ICAs, MRI markers of CSVD and MetS severity Z-score

Model 1Model 2
β/OR (95% CI)P valueβ/OR (95% CI)P value
Presence of ICAS1.88 (1.50 to 2.34)<0.0011.75 (1.39 to 2.21)<0.001
CSVD markers
 WMH volume0.16 (0.07 to 0.24)<0.0010.11 (0.01 to 0.20)0.02
 Presence of lacunes1.40 (1.14 to 1.72)0.0021.28 (1.03 to 1.59)0.03
 Presence of CMBs0.98 (0.79 to 1.22)0.860.93 (0.74 to 1.16)0.51
 EPVS in basal ganglia0.97 (0.86 to 1.11)0.690.96 (0.84 to 1.09)0.51
 EPVS in white matter1.13 (1.00 to 1.27)0.061.09 (0.96 to 1.23)0.21
  • Results are from logistic regression analysis for ICAS, the prevalence of lacunes, CMBs and EPVS; ORs (95% CI) are shown. Multiple regression analysis was performed for WMHs volume; β (95% CI) represents the change in the log-transformed WMHs volume per SD increase in MetS score. The log-transformed WMHs volume was used in the regression analysis. Model 1: adjusted for age and sex. Model 2: adjusted as in model 1+use of antihyperlipidaemic medication, use of antihypertensive medication, use of antidiabetic medication and current smoking status.

  • CMBs, cerebral microbleeds; CSVD, cerebral small vessel disease; EPVS, enlarged perivascular spaces; ICAS, intracranial atherosclerotic stenosis; MetS, metabolic syndrome; WMHs, white matter hyperintensities.