HRs and 95% CIs of IS according to different cumulative burden of lipid parameters
| Events, N=1023 | Incidence rate | Model 1 | Model 2 | Model 3 | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| TG burden (mmol/L) | |||||
| 0 | 709 | 2.22 | Reference | Reference | Reference |
| 1 | 100 | 2.53 | 1.23 (1.00 to 1.52) | 1.25 (1.02 to 1.55) | 1.17 (0.95 to 1.44) |
| 2 | 104 | 2.63 | 1.34 (1.09 to 1.65) | 1.33 (1.08 to 1.64) | 1.22 (0.99 to 1.50) |
| 3 | 110 | 2.78 | 1.48 (1.21 to 1.82) | 1.42 (1.15 to 1.74) | 1.26 (1.02 to 1.55) |
| P for trend | 0.0082 | 0.0194 | 0.18 | ||
| TC burden (mmol/L) | |||||
| 0 | 425 | 1.94 | Reference | Reference | Reference |
| 1 | 172 | 2.36 | 1.18 (0.99 to 1.41) | 1.20 (1.00 to 1.43) | 1.18 (0.99 to 1.41) |
| 2 | 212 | 2.9 | 1.39 (1.18 to 1.64) | 1.39 (1.18 to 1.64) | 1.32 (1.11 to 1.560) |
| 3 | 214 | 2.93 | 1.42 (1.21 to 1.68) | 1.42 (1.20 to 1.67) | 1.33 (1.12 to 1.57) |
| P for trend | 0.0036 | 0.0051 | 0.035 | ||
| LDL-C burden (mmol/L) | |||||
| 0 | 315 | 1.9 | Reference | Reference | Reference |
| 1 | 212 | 2.34 | 1.30 (1.09 to 1.55) | 1.31 (1.09 to 1.56) | 1.31 (1.10 to 1.57) |
| 2 | 212 | 2.33 | 1.23 (1.04 to 1.47) | 1.24 (1.04 to 1.48) | 1.22 (1.03 to 1.46) |
| 3 | 284 | 3.13 | 1.50 (1.28 to 1.76) | 1.52 (1.29 to 1.79) | 1.47 (1.25 to 1.73) |
| P for trend | 0.0032 | 0.0013 | 0.005 | ||
| HDL-C burden (mmol/L) | |||||
| 0 | 920 | 2.3 | Reference | Reference | Reference |
| 1 | 26 | 2.08 | 0.85 (0.58 to 1.26) | 0.82 (0.55 to 1.22) | 0.78 (0.52 to 1.16) |
| 2 | 40 | 3.19 | 1.34 (0.98 to 1.84) | 1.34 (0.98 to 1.84) | 1.24 (0.90 to 1.71) |
| 3 | 37 | 2.96 | 1.20 (0.86 to 1.66) | 1.19 (0.86 to 1.66) | 1.09 (0.79 to 1.52) |
| P for trend | 0.16 | 0.18 | 0.48 | ||
| Non-HDL-C burden (mmol/L) | |||||
| 0 | 242 | 1.71 | Reference | Reference | Reference |
| 1 | 199 | 2.01 | 1.17 (0.97 to 1.41) | 1.16 (0.96 to 1.41) | 1.14 (0.94 to 1.37) |
| 2 | 270 | 2.73 | 1.51 (1.27 to 1.80) | 1.51 (1.27 to 1.80) | 1.45 (1.21 to 1.72) |
| 3 | 312 | 3.15 | 1.68 (1.42 to 1.99) | 1.67 (1.41 to 1.98) | 1.51 (1.28 to 1.80) |
| P for trend | <0.0001 | <0.0001 | 0.004 | ||
Model 1 was adjusted for age and sex.
Model 2 was adjusted for model 1 plus BMI (≥30 kg/㎡, 25–29.9 kg/㎡, 18.5–24.9 kg/㎡ and <18.5 kg/㎡) and physical activity, smoker and alcohol intake.
Model 3 was adjusted for model 2 plus history of hypertension, diabetes mellitus and hypercholesterolaemia.
BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; IS, ischaemic stroke; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride.