Outcome measures
| Early window patients with EVT <6.5 hours after onset or LSW (n=3158) | Late window patients with EVT ≥6.5 hours after onset or LSW (n=106) | P value* | |
| Primary outcome | |||
| Median 3-month mRS score (IQR) | 3 (2–6) (n=2948) | 3 (2–5) (n=104) | 0.92 |
| Secondary outcomes | |||
| Functional independence (3-month mRS 0–2) | 40.5% (1193/2948) | 43.3% (45/104) | 0.57 |
| Successful reperfusion (eTICI ≥2B) | 61.7% (1897/3076) | 56.9% (58/102) | 0.33 |
| Significant early clinical improvement (≥4 points decrease on NIHSS or NIHSS 0) | 54.7% (1542/2820) | 46.5% (46/99) | 0.11 |
| Safety outcomes | |||
| Peri-interventional complications | 8.7% (274/3158) | 9.4% (10/106) | 0.79 |
| Symptomatic intracranial haemorrhage | 5.9% (185/3158) | 4.7% (5/106) | 0.62 |
| Mortality at 3 months | 28.9% (853/2948) | 24.0% (25/104) | 0.28 |
*Mann-Whitney U test for difference in 3-month mRS score and χ2 tests for difference in proportions of other outcomes.
eTICI, extended Treatment In Cerebral Infarction; EVT, endovascular treatment; LSW, last seen well; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.