Table 2

Trials of direct mechanical thrombectomy or bridge treatment in an early time window

SKIP*DIRECT
MT*
DEVT*DIRECT
SAFE
SWIFT directMR CLEAN NO IV
Trial registrationUMIN000021488NCT03469206 ChiCTR-IOR-17013568 NCT03494920NCT03192332ISRCTN80619088
Nation and regionJapanChinaChinaAustraliaEurope,
North American
Europe
Number of centres (n)234133333920
Participants (n)204656234780404540
Time-windowPuncture within 4 hours from onsetIVT within 4.5 hours from onset4.5 hours from symptoms onsetIVT within 4.5 hours from onsetIVT within 4.5 hours from onsetIVT within 4.5 hours from onset
Alteplase0.6 mg/kg0.9 mg/kg
Maximum 90 mg
0.9 mg/kg
Maximum 90 mg
0.9 mg/kg
Maximum 90 mg
0.9 mg/kg
Maximum 90 mg
0.9 mg/kg
Maximum 90 mg
Expected completion dateJuly 2019December 2019July 2020May 2021December 2023April 2022
  • *The SKIP, DIRECT-MT and DEVT trials have been completed.

  • IVT, intravenous thrombolysis.