Lipids burden related residual risk beyond LDL-C in participants with low cumulative LDL-C burden
| Cumulative LDL-C =0 | IS | ||||
| Events, N=315 | Incidence rate (%) | Model 1 | Model 2 | Model 3 | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| TG burden (mmol/L) | |||||
| 0 | 221 | 1.73 | Reference | Reference | Reference |
| 1 | 21 | 1.81 | 1.06 (0.68 to 1.65) | 1.08 (0.69 to 1.69) | 1.01 (0.65 to 1.59) |
| 2 | 26 | 2.13 | 1.34 (0.89 to 2.01) | 1.34 (0.89 to 2.01) | 1.20 (0.80 to 1.82) |
| 3 | 47 | 3.23 | 2.00 (1.45 to 2.75) | 1.87 (1.35 to 2.59) | 1.65 (1.19 to 2.31) |
| P for trend | <0.0001 | 0.0002 | 0.005 | ||
| TC burden (mmol/L) | |||||
| 0 | 216 | 1.75 | Reference | Reference | Reference |
| 1 | 37 | 1.68 | 0.92 (0.65 to 1.31) | 0.94 (0.66 to 1.34) | 0.91 (0.64 to 1.29) |
| 2 | 40 | 2.74 | 1.43 (1.02 to 2.00) | 1.42 (1.00 to 2.00) | 1.35 (0.95 to 1.90) |
| 3 | 22 | 3.61 | 1.88 (1.21 to 2.92) | 1.80 (1.14 to 2.82) | 1.63 (1.03 to 2.57) |
| P for trend | 0.0032 | 0.0063 | 0.024 | ||
| HDL burden (mmol/L) | |||||
| 0 | 275 | 1.86 | Reference | Reference | Reference |
| 1 | 11 | 1.97 | 1.08 (0.59 to 1.97) | 0.92 (0.47 to 1.80) | 0.94 (0.48 to 1.84) |
| 2 | 14 | 2.20 | 1.20 (0.70 to 2.05) | 1.16 (0.66 to 2.04) | 1.11 (0.63 to 1.94) |
| 3 | 15 | 2.33 | 1.15 (0.69 to 1.91) | 1.02 (0.58 to 1.79) | 0.98 (0.56 to 1.72) |
| P for trend | 0.59 | 0.78 | 0.95 | ||
| Non-HDL burden (mmol/L) | |||||
| 0 | 160 | 1.63 | Reference | Reference | Reference |
| 1 | 63 | 1.81 | 1.09 (0.81 to 1.46) | 1.08 (0.80 to 1.45) | 1.04 (0.77 to 1.40) |
| 2 | 60 | 2.63 | 1.51 (1.12 to 2.03) | 1.52 (1.13 to 2.05) | 1.41 (1.04 to 1.90) |
| 3 | 32 | 3.21 | 1.81 (1.24 to 2.64) | 1.78 (1.20 to 2.62) | 1.57 (1.06 to 2.32) |
| P for trend | 0.0003 | 0.0004 | 0.005 | ||
Model 1 was adjusted for age and sex.
Model 2 was adjusted for model 1 plus BMI (≥30 kg/㎡, 25–29.9 kg/㎡, 18.5–24.9 kg/㎡ and <18.5 kg/㎡) and physical activity, smoker and alcohol intake.
Model 3 was adjusted for model 2 plus updated hypertension, diabetes mellitus and hypercholesterolaemia.
HDL, high-density lipoprotein; IS, ischaemic stroke; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride.