Table 3

Lipids burden related residual risk beyond LDL-C in participants with low cumulative LDL-C burden

Cumulative LDL-C =0IS
Events, N=315Incidence rate (%)Model 1Model 2Model 3
HR (95% CI)HR (95% CI)HR (95% CI)
TG burden (mmol/L)
02211.73ReferenceReferenceReference
1211.811.06 (0.68 to 1.65)1.08 (0.69 to 1.69)1.01 (0.65 to 1.59)
2262.131.34 (0.89 to 2.01)1.34 (0.89 to 2.01)1.20 (0.80 to 1.82)
3473.232.00 (1.45 to 2.75)1.87 (1.35 to 2.59)1.65 (1.19 to 2.31)
P for trend<0.00010.00020.005
TC burden (mmol/L)
02161.75ReferenceReferenceReference
1371.680.92 (0.65 to 1.31)0.94 (0.66 to 1.34)0.91 (0.64 to 1.29)
2402.741.43 (1.02 to 2.00)1.42 (1.00 to 2.00)1.35 (0.95 to 1.90)
3223.611.88 (1.21 to 2.92)1.80 (1.14 to 2.82)1.63 (1.03 to 2.57)
P for trend0.00320.00630.024
HDL burden (mmol/L)
02751.86ReferenceReferenceReference
1111.971.08 (0.59 to 1.97)0.92 (0.47 to 1.80)0.94 (0.48 to 1.84)
2142.201.20 (0.70 to 2.05)1.16 (0.66 to 2.04)1.11 (0.63 to 1.94)
3152.331.15 (0.69 to 1.91)1.02 (0.58 to 1.79)0.98 (0.56 to 1.72)
P for trend0.590.780.95
Non-HDL burden (mmol/L)
01601.63ReferenceReferenceReference
1631.811.09 (0.81 to 1.46)1.08 (0.80 to 1.45)1.04 (0.77 to 1.40)
2602.631.51 (1.12 to 2.03)1.52 (1.13 to 2.05)1.41 (1.04 to 1.90)
3323.211.81 (1.24 to 2.64)1.78 (1.20 to 2.62)1.57 (1.06 to 2.32)
P for trend0.00030.00040.005
  • Model 1 was adjusted for age and sex.

  • Model 2 was adjusted for model 1 plus BMI (≥30 kg/㎡, 25–29.9 kg/㎡, 18.5–24.9 kg/㎡ and <18.5 kg/㎡) and physical activity, smoker and alcohol intake.

  • Model 3 was adjusted for model 2 plus updated hypertension, diabetes mellitus and hypercholesterolaemia.

  • HDL, high-density lipoprotein; IS, ischaemic stroke; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride.