Sensitivity analysis for different methods of adjustment
| Outcome | Adjusted OR or mean difference (95% CI)* | P value | Adjusted OR or mean difference (95% CI)† | P value |
| mRS scores 0 to 1 at 90 days | 1.19 (1.00 to 1.42) | 0.047 | 1.15 (0.98 to 1.35) | 0.078 |
| mRS scores 0 to 2 at 90 days | 1.27 (1.04 to 1.56) | 0.021 | 1.22 (1.01 to 1.46) | 0.036 |
| mRS distribution at 90 days | 0.060 | 0.140 | ||
| ΔNIHSS score to 24 hours‡ | 0.24 (−0.07 to 0.55) | 0.125 | 0.23 (−0.10 to 0.57) | 0.173 |
| ΔNIHSS score to 14 days‡ | 0.28 (−0.09 to 0.65) | 0.133 | 0.28 (−0.14 to 0.70) | 0.194 |
| sICH at 36 hours | 0.72 (0.36 to 1.43) | 0.349 | 0.69 (0.35 to 1.35) | 0.281 |
| Other bleeding events | 1.43 (0.64 to 3.19) | 0.384 | 1.48 (0.66 to 3.29) | 0.341 |
| Recurrent stroke at 90 days | 0.57 (0.34 to 0.95) | 0.030 | 0.57 (0.34 to 0.94) | 0.028 |
| All-cause mortality at 90 days | 0.74 (0.49 to 1.11) | 0.148 | 0.76 (0.52 to 1.12) | 0.164 |
*Adjustment with all baseline variables in the model.
†Propensity scores used to adjust all baseline variables in the model.
‡From baseline.
mRS, modified Rankin scale; NIHSS, National Institutes of Health Stroke Scale; rt-PA, recombinant tissue plasminogen activator; sICH, symptomatic intracerebral haemorrhage; UK, urokinase.