Subgroup and sensitivity analyses of the association of depressive symptoms with cardiometabolic diseases and all-cause mortality
| Transition A | Transition B | Transition C | Transition D | Transition E | Transition F | Transition G | |
| Subgroup analyses | |||||||
| Men | 1.11 (0.99 to 1.25) | 1.31 (1.12 to 1.54) | 1.25 (1.13 to 1.39) | 1.51 (1.39 to 1.63) | 1.56 (1.15 to 2.13) | 1.44 (1.05 to 1.97) | 1.47 (1.13 to 1.92) |
| Women | 1.12 (1.03 to 1.22) | 1.30 (1.15 to 1.48) | 1.26 (1.16 to 1.36) | 1.34 (1.25 to 1.44) | 1.56 (1.17 to 2.08) | 1.16 (0.83 to 1.60) | 1.05 (0.83 to 1.32) |
| Sensitivity analysis 1 | |||||||
| Depressive symptoms | 1.10 (1.03 to 1.18) | 1.32 (1.19 to 1.46) | 1.29 (1.21 to 1.37) | 1.40 (1.33 to 1.48) | 1.42 (1.14 to 1.77) | 1.28 (1.02 to 1.61) | 1.24 (1.04 to 1.48) |
| Sensitivity analysis 2 | |||||||
| Depressive symptoms | 1.12 (1.05 to 1.20) | 1.31 (1.18 to 1.45) | 1.25 (1.17 to 1.33) | 1.38 (1.30 to 1.46) | 1.54 (1.23 to 1.91) | 1.27 (1.00, 1.61) | 1.14 (0.95,1.38) |
Transitions: A (health to diabetes); B (health to stroke); C (health to heart disease); D (health to all-cause mortality); E (diabetes to mortality); F (stroke to mortality); and G (heart disease to mortality). Sensitivity analysis 1 excluded people with missing values of covariates (N=2461). Sensitivity analysis 2 excluded people with baseline cancer and Parkinson’s diseases (N=4842). Models were adjusted for age, gender, obesity, smoking, drinking, physical activity, marital status, education, taking medication for depression or anxiety, country and number of diseases at baseline.