Demographics and clinical outcomes between the off-hour group and the on-hour group
| Variable | Defined off-hour with arrival time (arrival mode) | P value | Defined off-hour with groin-puncture time (puncture mode) | P value | ||
| Off-hour n=435 | On-hour n=263 | Off-hour n=456 | On-hour n=242 | |||
| Age, year, median (IQR) | 65.0 (57.0–73.0) | 66.0 (56.0–75.0) | 0.587 | 65.0 (57.0–73.0) | 66.0 (56.0–75.0) | 0.831 |
| Male, n (%) | 282 (64.8) | 141 (53.6) | 0.003 | 285 (62.5) | 138 (57.0) | 0.159 |
| SBP, mm Hg, median (IQR) | 145.0 (130.0–160.0) | 146.0 (129.0–160.0) | 0.624 | 145.0 (130.0–160.8) | 145.0 (127.5–160.0) | 0.474 |
| DBP, mm Hg, median (IQR) | 82.0 (76.0–92.0) | 83.0 (74.0–93.0) | 0.697 | 83.0 (76.0–92.0) | 80.0 (72.0–93.0) | 0.079 |
| Glucose, mmol/L, median (IQR) | 6.8 (5.8–8.6) | 6.5 (5.5–8.6) | 0.082 | 6.8 (5.8–8.6) | 6.4 (5.5–8.4) | 0.024 |
| Medical history, n (%) | ||||||
| Atrial fibrillation | 177 (40.7) | 111 (42.2) | 0.693 | 189 (41.4) | 99 (40.9) | 0.891 |
| Hypertension | 278 (63.9) | 164 (62.4) | 0.680 | 290 (63.6) | 152 (62.8) | 0.837 |
| Diabetes | 80 (18.4) | 48 (18.3) | 0.963 | 85 (18.6) | 43 (17.8) | 0.777 |
| Current smoking, n (%) | 123 (28.3) | 61 (23.2) | 0.140 | 131 (28.7) | 53 (21.9) | 0.051 |
| ASPECTS, median (IQR) | 9.0 (8.0–10.0) | 9.0 (8.0–10.0) | 0.932 | 9.0 (8.0–10.0) | 9.0 (8.0–10.0) | 0.925 |
| Baseline NIHSS, median (IQR) | 16.0 (12.0–20.0) | 17.0 (12.0–21.0) | 0.154 | 16.0 (12.0–20.0) | 17.0 (12.0–21.0) | 0.071 |
| Intravenous thrombolysis, n (%) | 153 (35.2) | 76 (28.9) | 0.087 | 158 (34.6) | 71 (29.3) | 0.155 |
| Local anaesthesia, n (%) | 358 (82.3) | 202 (76.8) | 0.077 | 373 (81.8) | 187 (77.3) | 0.153 |
| Stroke aetiology, n (%) | 0.669 | 0.950 | ||||
| LAA | 191 (43.9) | 118 (44.9) | 202 (44.3) | 107 (44.2) | ||
| CE | 216 (49.7) | 124 (47.1) | 223 (48.9) | 117 (48.3) | ||
| Others | 28 (6.4) | 21 (8.0) | 31 (6.8) | 18 (7.4) | ||
| ICA occlusion, n (%) | 174 (40.0) | 107 (40.7) | 0.858 | 187 (41.0) | 94 (38.8) | 0.579 |
| MCA occlusion, n (%) | 257 (59.1) | 154 (58.6) | 0.891 | 264 (57.9) | 147 (60.7) | 0.467 |
| ASITN/SIR 0–1, n (%) | 221 (50.8) | 117 (44.5) | 0.106 | 226 (49.6) | 112 (46.3) | 0.409 |
| Onset to door, min, median (IQR) | 120.0 (60.0–212.0) | 140.0 (64.0–240.0) | 0.047 | 125.0 (60.0–220.0) | 127.0 (63.5–232.5) | 0.542 |
| Door to imaging, min, median (IQR) | 23.0 (12.0–33.0) | 24.0 (13.0–32.0) | 0.940 | 23.0 (12.0–34.0) | 24.0 (15.0–32.0) | 0.885 |
| Door to puncture, min, median (IQR) | 128.0 (84.0–177.0) | 125.0 (80.0–172.0) | 0.597 | 130.0 (86.3–177.0) | 120.0 (75.0–165.0) | 0.161 |
| Puncture to reperfusion, min, median (IQR) | 100.0 (72.0–145.0) | 101.0 (77.0–138.0) | 0.858 | 99.5 (70.0–140.8) | 103.0 (79.8–143.5) | 0.235 |
| Onset to puncture, min, median (IQR) | 266.0 (201.0–345.0) | 285.0 (210.0–360.0) | 0.098 | 273.5 (204.3–349.5) | 270.5 (210.0–360.0) | 0.711 |
| Onset to reperfusion, min, median (IQR) | 380.0 (299.0–470.0) | 383.0 (310.0–488.0) | 0.393 | 382.0 (299.0–470.0) | 380.5 (313.0–488.5) | 0.656 |
| Successful reperfusion, n (%) | 361 (83.0) | 218 (82.9) | 0.973 | 378 (82.9) | 201 (83.1) | 0.957 |
| Symptomatic ICH, n (%) | 69 (15.9) | 39 (14.8) | 0.715 | 74 (16.2) | 34 (14.0) | 0.449 |
| Asymptomatic ICH, n (%) | 140 (32.2) | 78 (29.7) | 0.485 | 144 (31.6) | 74 (30.6) | 0.786 |
| Mortality in hospital, n (%) | 104 (23.9) | 59 (22.4) | 0.655 | 110 (24.1) | 53 (21.9) | 0.509 |
| mRS score at 90 days, median (IQR) | 3 (1–6) | 3 (1–6) | 0.624 | 3 (1–6) | 3 (2–6) | 0.549 |
| Favourable outcome, n (%) | 190 (43.7) | 114 (43.3) | 0.932 | 200 (43.9) | 104 (43.0) | 0.823 |
| Mortality at 90 days, n (%) | 109 (25.1) | 68 (25.9) | 0.814 | 116 (25.4) | 61 (25.2) | 0.947 |
ASITN/SIR, American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology; ASPECTS, Alberta Stroke Program Early CT Score; CE, cardioembolism; DBP, diastolic blood pressure; ICA, intracranial artery; ICH, intracranial haemorrhage; LAA, large-artery atherosclerosis; MCA, middle cerebral artery; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; SBP, systolic blood pressure.