Table 3

Logistic regression analysis in matched patients

	Matched late window patients with EVT ≥6.5 hours vs early window patients with EVT <6.5 hours after onset or LSW*
	Unadjusted OR (95% CI)	P value	Adjusted OR (95% CI)†	P value
Primary outcome
3-month mRS score reduction (shift analysis)‡	0.99 (0.59 to 1.67)	0.98	1.04 (0.56 to 1.93)	0.89
Secondary outcomes
Functional independence (3-month mRS 0–2)	1.05 (0.63 to 1.75)	0.87	1.17 (0.58 to 2.37)	0.65
Successful reperfusion (eTICI ≥2B)	0.75 (0.41 to 1.38)	0.35	0.75 (0.41 to 1.39)	0.35
Significant early clinical improvement (≥4 points decrease on NIHSS or NIHSS 0)	0.78 (0.45 to 1.32)	0.35	0.79 (0.44 to 1.43)	0.43
Safety outcomes
Peri-interventional complications	1.49 (0.52 to 4.24)	0.45	1.52 (0.50 to 4.58)	0.45
Symptomatic intracranial haemorrhage	0.99 (0.28 to 3.52)	0.98	1.03 (0.26 to 4.04)	0.97
Mortality at 3 months	0.84 (0.43 to 1.65)	0.61	0.76 (0.32 to 1.79)	0.52

*Matched on: age, prestroke mRS, NIHSS at presentation, ASPECTS at presentation, location of occlusion, collateral status and treatment with IVT. With a calliper of 0.2, 511 (96.4%) of the 530 late window patients treated beyond 6.5 hours (5 datasets with 106 late window patients per dataset) could be matched in a 1:2 ratio to 1022 early window patients treated within 6.5 hours. ORs were pooled from the five matched datasets using Rubin’s rules.
†Adjusted for: age, prestroke mRS, NIHSS at presentation, ASPECTS at presentation, location of occlusion, collateral status and treatment with IVT.
‡Common OR indicating the odds of improvement of 1 point on the mRS.
eTICI, extended Treatment In Cerebral Infarction; EVT, endovascular treatment; LSW, last seen well; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.