Time metrics and clinical outcomes between the true off-hour group and the true on-hour group
| Variable | Overall n=595 | True off-hour n=394 | True on-hour n=201 | Adjusted ß coefficient/OR (95% CI)* | P value |
| Onset to door, min, median (IQR) | 131.0 (60.0–230.0) | 124.5 (60.0–218.2) | 146.0 (73.5–240.0) | −15.56 (−35.78 to 4.65) | 0.131 |
| Door to imaging, min, median (IQR) | 22.0 (12.0–32.0) | 22.0 (11.8–32.2) | 23.0 (12.0–30.5) | −0.37 (−4.30 to 3.56) | 0.855 |
| Door to puncture, min, median (IQR) | 120.0 (76.0–164.0) | 125.0 (80.0–170.2) | 116.0 (67.0–150.0) | 12.17 (−1.20 to 25.55) | 0.074 |
| Puncture to reperfusion, min, median (IQR) | 100.0 (74.0–143.0) | 100.0 (71.0–144.2) | 103.0 (78.5–140.5) | −0.57 (−10.93 to 9.79) | 0.914 |
| Onset to puncture, min, median (IQR) | 270.0 (203.0–348.0) | 265.5 (200.0–345.0) | 271.0 (210.0–359.0) | −3.39 (−24.78 to 17.99) | 0.755 |
| Onset to reperfusion, min, median (IQR) | 374.0 (300.0–470.0) | 374.5 (294.0–463.8) | 372.0 (312.0–485.5) | −5.10 (−29.14 to 18.94) | 0.677 |
| Successful reperfusion, n (%) | 494 (83.0) | 327 (83.0) | 167 (83.1) | 0.96 (0.60 to 1.54) | 0.878 |
| Symptomatic ICH, n (%) | 95 (16.0) | 65 (16.5) | 30 (14.9) | 1.20 (0.73 to 1.95) | 0.474 |
| Asymptomatic ICH, n (%) | 186 (31.3) | 126 (32.0) | 60 (29.9) | 1.13 (0.77 to 1.65) | 0.525 |
| Mortality in hospital, n (%) | 141 (23.7) | 96 (24.4) | 45 (22.4) | 1.28 (0.82 to 2.00) | 0.281 |
| 90-day mRS score, median (IQR) | 3.0 (1.0–6.0) | 3.0 (1.0–6.0) | 3.0 (2.0–6.0) | 0.97 (0.71 to 1.32) | 0.848 |
| Favourable outcome, n (%) | 252 (42.4) | 169 (42.9) | 83 (41.3) | 0.95 (0.65 to 1.40) | 0.790 |
| Mortality at 90 days, n (%) | 154 (25.9) | 101 (25.6) | 53 (26.4) | 1.09 (0.71 to 1.67) | 0.692 |
Reference: patients who presented or get treated during the on-hour period.
*Time metrics were adjusted for gender, glucose level, current smoking, baseline National Institute of Health Stroke Scale (NIHSS) score, intravenous thrombolysis, local anaesthesia. Other clinical outcomes were adjusted for gender, glucose level, current smoking, baseline NIHSS score, intravenous thrombolysis, local anaesthesia, onset to door time and door to puncture time.
ICH, intracranial haemorrhage; mRS, modified Rankin Scale.;