Table 2

Predictors of 3-month excellent outcome after IVT

3-month mRS score 0–1
Bivariate (n=247)Multivariate (n=247)
OR95% CIP valueOR95% CIP value
Sociodemographics features
Age0.990.97 to 1.010.36
Sex: male versus female0.620.36 to 1.070.09
Comorbidities and risk factors
Hypertension: absence versus presence1.871.42 to 2.47 0.024 2.431.74 to 3.380.0074
Diabetes: absence versus presence1.830.80 to 4.220.15
Current smoking: absence versus presence1.861.30 to 2.660.0832.761.79 to 4.260.019
Baseline clinical examination
NIHSS score, pts*0.900.84 to 0.96 0.0018
Systolic blood pressure, mm Hg*1.000.99 to 1.010.91
Glycaemia, g/L*0.390.17 to 0.92 0.031
Temperature, °C*1.230.74 to 2.050.43
Hour*0.530.35 to 0.83 0.0048 0.470.23 to 0.780.0033
Imaging features
Imaging technique: CT versus MRI0.640.32 to 1.250.19
DWI volume, 10 mL†‡0.850.77 to 0.94 0.0016 0.780.68 to 0.890.0004
Infarct territory 0.0033
 Superficial MCAReference
 Deep MCA0.860.35 to 2.080.73
 Superficial and deep MCA0.340.14 to 0.81 0.015
 Other0.410.07 to 2.230.30
Thrombus length‡
 HMCAS length, mm*0.950.91 to 1.00 0.030 0.980.92 to 1.030.37
 SVS length, mm*0.960.93 to 0.99 0.017 0.870.80 to 0.940.0012
Occlusion site: M1 versus C14.661.61 to 13.52 0.0046
Clot burden score‡
 CT, pts*1.231.00 to 1.50 0.046
 MRI, pts*1.261.07 to 1.47 0.0053
 HMCAS: presence versus absence0.870.25 to 2.990.830.800.22 to 2.990.74
 SVS: presence versus absence0.840.40 to 1.770.657.891.65 to 37.780.0097
FVH/DWI mismatch: yes versus no‡2.711.19 to 6.20 0.018
ASPECT-FVH score, pts*‡1.090.93 to 1.270.31
DWM Fazekas score, pts‡
 CT, pts*0.68<0.01 to >1000.99
 MRI, pts*0.790.56 to 1.100.16
  • 3-month excellent outcome after IVT defined by a 3-month mRS score ≤1.

  • All ORs are calculated for 3-month mRS score ≤2.

  • Bold values shows p<0.05.

  • *ORs express the risk variation for a unit increase of the variable.

  • †ORs express the risk variation for 10 mL increase in the ischaemic core volume on DWI.

  • ‡Nested effect is adjusted on the nesting characteristics, that is, imaging type, to consider effect differently in CT and in MRI.

  • ASPECTS-FVH score, Alberta Stroke Programme Early CT score and extent of FLAIR vascular hyperintensities (0–6); C1, distal internal carotid artery; clot burden score (0–10); DWI, diffusion-weighted imaging; DWI volume, ischaemic core volume on DWI; DWM Fazekas score, deep white matter Fazekas score (0–3); FVH/DWI mismatch, FLAIR vascular hyperintensity and DWI infarct hyperintensity mismatch; HMCAS/SVS, hyper-dense MCA sign on CT or susceptibility vessel sign on T2*-MRI; IVT, intravenous thrombolysis; M1, first segment of MCA; MCA, middle cerebral artery; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke scale; OTT, onset-to-treatment time; pts, patients.