Table 2

Summary of patient demographics and clinical features

1*2345678910Median
Age (years)5251606255576654664856.00
SexFemaleMaleMaleMaleMaleMaleMaleFemaleMaleMale
Premorbid condition
 HypertensionYesYesYesYesYes –
 Chronic kidney diseaseYesYes –Yes –
 Diabetes mellitusType 2Type 2Type 1Type 2
 ObesityYesYes –
 HypercholesterolaemiaYesYes –Yes
 Respiratory
 condition
 –COPD –
 OtherMultiple myelomaSitus inversus –IHDPolymyalgia
ARDSYesYesYesYesYesYesYesYesYesYes
Reason for ITU admissionT1RFT1RFT1RFT1RFT1RFT1RFT1RFT1RFT1RFT1RF
Length of
intubation (days)
122925252221433338525.00
ECMO duration (days) – –140
HaemodialysisCVVHDFCVVHDFCVVHDFCVVHDFCVVHDFCVVHDFCVVHDF
HeparinisationYesYesYesYesYesYesYesYesYesYes
Neurological presentationAMSAMSAMSRight-side weaknessAMSAMSAMSAbnormal ventilationTremorsSeizures
Highest recorded blood pressure190/70150/112110/80143/96208/69163/74172/81137/77142/91
Biochemistry and haematology, worst value
 pH (7.35–7.45) –7.127.157.057.057.097.196.957.137.157.12
 PaCO2 (4.7–6 kPa) –11.39.919.411.414.27.917.714.916.114.20
 PaO2 (10.0–13.3 kPa) –5.98.46.64.15.36.58.18.28.16.60
 LDH (125–243 units/L)6093457744101096663533229591837600.00
 Hb (115–155 g/L)7268687168736364669168.00
 WCC (4.2–10.6×109/L)14.419.931.620.429.914.619.325.624.331.322.35
 Lymphocytes (1.1–3.6×109/L)2.20.40.60.30.60.50.20.30.30.70.45
 Neutrophils (2.0–7.1×109/L)10.317.315.918.415.716.317.824.122.125.617.55
 Platelets (highest/lowest)
 (130–370×109/L)
537/438732/189318/100285/142525/175342/143298/102547/138733/369871/280537/143
 Urea (2.5–7.8)44.314.95120.341.349.842.626.943.37.741.95
 CRP (<5 mg/L)49426342349401365220284266175313.00
 Ferritin (20–300 ng/mL)27143607376275694003739710526491612 5923684.50
 PT (12.8–17.4 s)15.618.52017.514.915.519.818.216.215.316.85
 Fibrinogen
 (1.9–4.3 g/L)
5.18.69.68.74.310.37.58.67.97.58.25
 D-dimer (<500 ng/mL)201020 00020 0007569630920 00012 064556913 14870609816.50
 Haematocrit (0.39%–0.50%)0.2240.4240.440.30.410.40.360.340.2890.410.38
DIC score34434444444.00
Systemic thrombosisNoNoNoNoNoNoIJV thrombusNoDVTNo
Extent of consolidation on thoracic imagingSevereSevereSevereSevereSevereSevereSevereSevereSevere
MRI head day from admission2438373229245359584137.50
MARS247025270214416393560.44
  • Bold values highlight the areas with the greatest median number of microhaemorrhages.

  • *Patient 1 has incomplete biochemistry information due to their initial care being at an external institution.

  • AMS, altered mental state; ARDS, acute respiratory distress syndrome; COPD, chronic obstructive pulmonary disease; CRP, c-reactive protein; CVVHDF, continuous venovenous haemodiafiltration; DIC, disseminated intravascular coagulation; ECMO, extracorporeal membrane oxygenation; Hb, haemoglobin; IHD, ischaemic heart disease; IJV, internal jugular vein; ITU, intensive therapy unit; LDH, lactate dehydrogenase; MARS, microbleed anatomical scale; Pa02, partial pressure of oxygen; PaC02, partial pressure of carbon dioxide; PT, prothrombin time; T1RF, type 1 respiratory failure; WCC, white cell count.