Summary of patient demographics and clinical features
| 1* | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | Median | |
| Age (years) | 52 | 51 | 60 | 62 | 55 | 57 | 66 | 54 | 66 | 48 | 56.00 |
| Sex | Female | Male | Male | Male | Male | Male | Male | Female | Male | Male | – |
| Premorbid condition | |||||||||||
| Hypertension | Yes | Yes | Yes | – | – | Yes | Yes | – | – | – | – |
| Chronic kidney disease | Yes | – | Yes | – | – | – | Yes | – | – | – | – |
| Diabetes mellitus | – | – | – | – | – | Type 2 | Type 2 | Type 1 | – | Type 2 | – |
| Obesity | – | – | – | – | Yes | – | Yes | – | – | – | – |
| Hypercholesterolaemia | – | – | – | – | – | Yes | Yes | – | – | Yes | – |
| Respiratory condition | – | – | – | – | – | – | COPD | – | – | – | – |
| Other | – | – | Multiple myeloma | Situs inversus | – | IHD | – | Polymyalgia | – | – | |
| ARDS | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | – |
| Reason for ITU admission | T1RF | T1RF | T1RF | T1RF | T1RF | T1RF | T1RF | T1RF | T1RF | T1RF | – |
| Length of intubation (days) | 12 | 29 | 25 | 25 | 22 | 21 | 43 | 33 | 38 | 5 | 25.00 |
| ECMO duration (days) | – | – | – | – | – | – | – | – | – | 14 | 0 |
| Haemodialysis | CVVHDF | – | CVVHDF | – | CVVHDF | CVVHDF | CVVHDF | CVVHDF | CVVHDF | – | – |
| Heparinisation | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | – |
| Neurological presentation | AMS | AMS | AMS | Right-side weakness | AMS | AMS | AMS | Abnormal ventilation | Tremors | Seizures | – |
| Highest recorded blood pressure | 190/70 | 150/112 | 110/80 | – | 143/96 | 208/69 | 163/74 | 172/81 | 137/77 | 142/91 | – |
| Biochemistry and haematology, worst value | |||||||||||
| pH (7.35–7.45) | – | 7.12 | 7.15 | 7.05 | 7.05 | 7.09 | 7.19 | 6.95 | 7.13 | 7.15 | 7.12 |
| PaCO2 (4.7–6 kPa) | – | 11.3 | 9.9 | 19.4 | 11.4 | 14.2 | 7.9 | 17.7 | 14.9 | 16.1 | 14.20 |
| PaO2 (10.0–13.3 kPa) | – | 5.9 | 8.4 | 6.6 | 4.1 | 5.3 | 6.5 | 8.1 | 8.2 | 8.1 | 6.60 |
| LDH (125–243 units/L) | 609 | 345 | 774 | 410 | 1096 | 663 | 533 | 229 | 591 | 837 | 600.00 |
| Hb (115–155 g/L) | 72 | 68 | 68 | 71 | 68 | 73 | 63 | 64 | 66 | 91 | 68.00 |
| WCC (4.2–10.6×109/L) | 14.4 | 19.9 | 31.6 | 20.4 | 29.9 | 14.6 | 19.3 | 25.6 | 24.3 | 31.3 | 22.35 |
| Lymphocytes (1.1–3.6×109/L) | 2.2 | 0.4 | 0.6 | 0.3 | 0.6 | 0.5 | 0.2 | 0.3 | 0.3 | 0.7 | 0.45 |
| Neutrophils (2.0–7.1×109/L) | 10.3 | 17.3 | 15.9 | 18.4 | 15.7 | 16.3 | 17.8 | 24.1 | 22.1 | 25.6 | 17.55 |
| Platelets (highest/lowest) (130–370×109/L) | 537/438 | 732/189 | 318/100 | 285/142 | 525/175 | 342/143 | 298/102 | 547/138 | 733/369 | 871/280 | 537/143 |
| Urea (2.5–7.8) | 44.3 | 14.9 | 51 | 20.3 | 41.3 | 49.8 | 42.6 | 26.9 | 43.3 | 7.7 | 41.95 |
| CRP (<5 mg/L) | 49 | 426 | 342 | 349 | 401 | 365 | 220 | 284 | 266 | 175 | 313.00 |
| Ferritin (20–300 ng/mL) | 2714 | 3607 | 3762 | 7569 | 4003 | 739 | 710 | 526 | 4916 | 12 592 | 3684.50 |
| PT (12.8–17.4 s) | 15.6 | 18.5 | 20 | 17.5 | 14.9 | 15.5 | 19.8 | 18.2 | 16.2 | 15.3 | 16.85 |
| Fibrinogen (1.9–4.3 g/L) | 5.1 | 8.6 | 9.6 | 8.7 | 4.3 | 10.3 | 7.5 | 8.6 | 7.9 | 7.5 | 8.25 |
| D-dimer (<500 ng/mL) | 2010 | 20 000 | 20 000 | 7569 | 6309 | 20 000 | 12 064 | 5569 | 13 148 | 7060 | 9816.50 |
| Haematocrit (0.39%–0.50%) | 0.224 | 0.424 | 0.44 | 0.3 | 0.41 | 0.4 | 0.36 | 0.34 | 0.289 | 0.41 | 0.38 |
| DIC score | 3 | 4 | 4 | 3 | 4 | 4 | 4 | 4 | 4 | 4 | 4.00 |
| Systemic thrombosis | No | No | No | No | No | No | IJV thrombus | No | DVT | No | |
| Extent of consolidation on thoracic imaging | – | Severe | Severe | Severe | Severe | Severe | Severe | Severe | Severe | Severe | |
| MRI head day from admission | 24 | 38 | 37 | 32 | 29 | 24 | 53 | 59 | 58 | 41 | 37.50 |
| MARS | 24 | 70 | 25 | 270 | 21 | 44 | – | 16 | 39 | 35 | 60.44 |
Bold values highlight the areas with the greatest median number of microhaemorrhages.
*Patient 1 has incomplete biochemistry information due to their initial care being at an external institution.
AMS, altered mental state; ARDS, acute respiratory distress syndrome; COPD, chronic obstructive pulmonary disease; CRP, c-reactive protein; CVVHDF, continuous venovenous haemodiafiltration; DIC, disseminated intravascular coagulation; ECMO, extracorporeal membrane oxygenation; Hb, haemoglobin; IHD, ischaemic heart disease; IJV, internal jugular vein; ITU, intensive therapy unit; LDH, lactate dehydrogenase; MARS, microbleed anatomical scale; Pa02, partial pressure of oxygen; PaC02, partial pressure of carbon dioxide; PT, prothrombin time; T1RF, type 1 respiratory failure; WCC, white cell count.