Analyses of 30-day safety endpoints by centre volume
| Outcomes | Patients (n=1140) | Volume of study centre | |||
| High (n=774) | Middle (n=294) | Low (n=72) | P value | ||
| Primary outcomes | 111 (9.7) | 42 (5.4) | 62 (21.1) | 7 (9.7) | <0.0001 |
| Ischaemic | 53 (4.7) | 21 (2.7) | 29 (9.9) | 3 (4.2) | <0.0001 |
| Perforator occlusion | 41 (3.6) | 18 (2.6) | 21 (7.1) | 2 (2.8) | 0.0007 |
| In-stent thrombosis | 8 (0.7) | 3 (0.4) | 4 (1.4) | 1 (1.4) | 0.2567 |
| Haemorrhagic | 58 (5.1) | 21 (2.7) | 33 (11.2) | 4 (5.6) | <0.0001 |
| SAH | 28 (2.5) | 12 (1.6) | 13 (4.4) | 3 (4.2) | <0.0001 |
| SICH | 30 (2.6) | 9 (1.2) | 20 (6.8) | 1 (1.4) | <0.0001 |
| Death | 12 (1.1) | 3 (0.4) | 9 (3.1) | 0 | 0.0004 |
SAH, subarachnoid haemorrhage; SICH, symptomatic intracranial/intraparenchymal haemorrhage.