Table 3

AD use and clinical outcomes at 1-year post-IS discharge by subgroups

Outcomes at one yearUnadjustedWeight adjustedNIHSS weight adjusted
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
All-cause mortality
0.3 0.615 0.661
 Age ≥80 years1.32 (1.18 to 1.48) <0.001 1.28 (1.14 to 1.43) <0.001 1.20 (1.06 to 1.36) 0.005
 Age <80 years1.46 (1.25 to 1.71) <0.001 1.34 (1.14 to 1.58) <0.001 1.26 (1.06 to 1.50) 0.01
0.826 0.674 0.697
 Female1.32 (1.17 to 1.49) <0.001 1.31 (1.15 to 1.48) <0.001 1.23 (1.08 to 1.40) 0.002
 Male1.29 (1.11 to 1.50) <0.001 1.25 (1.08 to 1.46) 0.004 1.18 (1.00 to 1.39)0.057
0.266 0.2934 0.348
 White1.29 (1.16 to 1.43) <0.001 1.25 (1.13 to 1.39) <0.001 1.18 (1.06 to 1.32) 0.003
 Non-white1.48 (1.19 to 1.85) <0.001 1.44 (1.15 to 1.80) 0.002 1.34 (1.06 to 1.71) 0.016
0.004 0.007 0.006
 NIHSS >41.08 (0.95 to 1.22)0.2371.08 (0.95 to 1.22)0.2581.08 (0.95 to 1.23)0.221
 NIHSS ≤41.47 (1.24 to 1.73) <0.001 1.44 (1.21 to 1.71) <0.001 1.46 (1.23 to 1.73) <0.001
0.021 0.016 0.008
History of depression Yes0.96 (0.73 to 1.27)0.7940.94 (0.72 to 1.24)0.6850.84 (0.63 to 1.13)0.254
History of depression No1.36 (1.23 to 1.49) <0.001 1.35 (1.22 to 1.49) <0.001 1.28 (1.15 to 1.43) <0.001
All-cause readmission
0.482 0.685 0.763
 Age ≥80 years1.20 (1.09 to 1.32) <0.001 1.17 (1.06 to 1.29) 0.002 1.14 (1.03 to 1.27) 0.011
 Age <80 years1.27 (1.14 to 1.40) <0.001 1.21 (1.09 to 1.34) <0.001 1.17 (1.05 to 1.31) 0.005
0.682 0.613 0.864
 Female1.20 (1.10 to 1.31) <0.001 1.17 (1.07 to 1.28) <0.001 1.15 (1.05 to 1.26) 0.004
 Male1.24 (1.12 to 1.37) <0.001 1.21 (1.09 to 1.35) <0.001 1.16 (1.04 to 1.30) 0.007
0.439 0.526 0.396
 White1.21 (1.13 to 1.30) <0.001 1.17 (1.09 to 1.26) <0.001 1.14 (1.06 to 1.23) <0.001
 Non-white1.30 (1.11 to 1.52) 0.001 1.24 (1.06 to 1.46) 0.009 1.24 (1.04 to 1.47) 0.016
0.104 0.234 0.226
 NIHSS >41.11 (1.01 to 1.22) 0.033 1.10 (1.00 to 1.21) 0.058 1.10 (1.00 to 1.21) 0.045
 NIHSS ≤41.25 (1.12 to 1.39) <0.001 1.20 (1.08 to 1.34) 0.001 1.21 (1.08 to 1.35) <0.001
0.011 0.008 0.016
History of depression yes0.96 (0.80 to 1.16)0.6920.94 (0.79 to 1.13)0.5420.92 (0.76 to 1.12)0.412
History of depression no1.24 (1.15 to 1.33) <0.001 1.23 (1.14 to 1.32) <0.001 1.20 (1.11 to 1.29) <0.001
MACE
0.522 0.722 0.829
 Age ≥80 years1.17 (1.06 to 1.29) 0.002 1.16 (1.05 to 1.28) 0.004 1.10 (0.99 to 1.23)0.074
 Age <80years1.23 (1.09 to 1.39) <0.001 1.19 (1.05 to 1.34) 0.005 1.12 (0.99 to 1.28)0.076
0.969 0.945 0.887
 Female1.17 (1.06 to 1.30) 0.001 1.17 (1.06 to 1.29) 0.003 1.12 (1.00 to 1.24) 0.043
 Male1.18 (1.05 to 1.32) 0.005 1.16 (1.03 to 1.31) 0.011 1.10 (0.97 to 1.25)0.139
0.557 0.568 0.684
 White1.17 (1.08 to 1.27) <0.001 1.15 (1.06 to 1.25) <0.001 1.10 (1.01 to 1.20) 0.026
 Non-white1.24 (1.04 to 1.48) 0.018 1.22 (1.02 to 1.47) 0.031 1.15 (0.95 to 1.39)0.146
0.008 0.022 0.021
 NIHSS >41.00 (0.90 to 1.11)0.9551.01 (0.91 to 1.12)0.8711.01 (0.91 to 1.13)0.805
 NIHSS ≤41.25 (1.11 to 1.41) <0.001 1.23 (1.08 to 1.39) 0.001 1.24 (1.09 to 1.40) <0.001
0.038 0.027 0.037
History of depression yes0.96 (0.78 to 1.18)0.6890.94 (0.76 to 1.16)0.5520.89 (0.71 to 1.11)0.302
History of depression no1.21 (1.12 to 1.31) <0.001 1.21 (1.12 to 1.31) <0.001 1.15 (1.06 to 1.25) 0.001
  • Italics denotes p value for the interaction of AD use and outcomes between subgroups.

  • Bold denotes statistically significant p value < 0.05.

  • AD, antidepressant; CV, cardiovascular; IS, ischaemic stroke; MACE, major adverse cardiac events; NIHSS, National Institutes of Health Stroke Scale.