ORs for newly developed carotid plaque for various level of lipid burdens in sensitivity analysis
| Newly developed carotid plaque | Newly developed vulnerable carotid plaque | |||
| Model 4 (95% CI) | Model 5 (95% CI) | Model 4 (95% CI) | Model 5 (95% CI) | |
| TC burden | ||||
| Q1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Q2 | 1.12 (0.87 to 1.44) | 1.09 (0.84 to 1.41) | 1.12 (0.88 to 1.42) | 1.08 (0.85 to 1.37) |
| Q3 | 1.31 (1.01 to 1.68) | 1.30 (1.00 to 1.68) | 1.31 (1.03 to 1.67) | 1.28 (1.01 to 1.63) |
| Q4 | 1.67 (1.29 to 2.15) | 1.54 (1.18 to 2.00) | 1.68 (1.32 to 2.14) | 1.49 (1.17 to 1.89) |
| P for trend | <0.001 | 0.003 | <0.001 | <0.001 |
| Continuous scale | 1.03 (1.01 to 1.05) | 1.03 (1.01 to 1.04) | 1.03 (1.02 to 1.05) | 1.03 (1.01 to 1.04) |
| TG burden | ||||
| Q1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Q2 | 1.04 (0.81 to 1.35) | 1.05 (0.81 to 1.37) | 1.05 (0.82 to 1.34) | 1.03 (0.82 to 1.31) |
| Q3 | 1.09 (0.84 to 1.43) | 1.15 (0.88 to 1.49) | 1.09 (0.85 to 1.40) | 1.14 (0.90 to 1.45) |
| Q4 | 1.65 (1.26 to 2.16) | 1.64 (1.24 to 2.16) | 1.56 (1.21 to 2.01) | 1.51 (1.18 to 1.95) |
| P for trend | 0.020 | 0.017 | 0.015 | 0.010 |
| Continuous scale | 1.01 (1.00 to 1.03) | 1.02 (1.00 to 1.03) | 1.01 (1.00 to 1.02) | 1.02 (1.00 to 1.03) |
| HDLC burden | ||||
| Q1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Q2 | 1.16 (0.90 to 1.48) | 1.20 (0.92 to 1.56) | 1.21 (0.95 to 1.54) | 1.23 (0.97 to 1.57) |
| Q3 | 0.96 (0.74 to 1.24) | 1.01 (0.77 to 1.32) | 1.03 (0.81 to 1.31) | 1.09 (0.85 to 1.39) |
| Q4 | 1.09 (0.84 to 1.41) | 1.17 (0.89 to 1.53) | 1.12 (0.87 to 1.43) | 1.17 (0.91 to 1.50) |
| P for trend | 0.454 | 0.166 | 0.433 | 0.182 |
| Continuous scale | 1.02 (0.97 to 1.07) | 1.04 (0.99 to 1.09) | 1.02 (0.97 to 1.07) | 1.03 (0.99 to 1.08) |
| LDLC burden | ||||
| Q1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Q2 | 0.98 (0.76 to 1.26) | 1.04 (0.80 to 1.35) | 1.03 (0.81 to 1.31) | 1.10 (0.87 to 1.40) |
| Q3 | 0.98 (0.77 to 1.26) | 0.94 (0.73 to 1.23) | 1.02 (0.80 to 1.29) | 1.04 (0.82 to 1.33) |
| Q4 | 1.20 (0.93 to 1.54) | 1.30 (1.00 to 1.69) | 1.19 (0.94 to 1.51) | 1.31 (1.03 to 1.67) |
| P for trend | 0.016 | 0.006 | 0.009 | 0.001 |
| Continuous scale | 1.03 (1.01 to 1.05) | 1.04 (1.01 to 1.06) | 1.03 (1.01 to 1.05) | 1.04 (1.01 to 1.06) |
| Non-HDLC burden | ||||
| Q1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Q2 | 1.21 (0.94 to 1.56) | 1.12 (0.87 to 1.45) | 1.26 (0.99 to 1.60) | 1.17 (0.92 to 1.48) |
| Q3 | 1.18 (0.91 to 1.52) | 1.15 (0.88 to 1.49) | 1.21 (0.95 to 1.55) | 1.16 (0.91 to 1.47) |
| Q4 | 1.56 (1.20 to 2.03) | 1.53 (1.17 to 2.01) | 1.60 (1.24 to 2.05) | 1.53 (1.20 to 1.96) |
| P for trend | 0.005 | 0.008 | <0.001 | <0.001 |
| Continuous scale | 1.02 (1.01 to 1.04) | 1.02 (1.01 to 1.04) | 1.02 (1.01 to 1.04) | 1.03 (1.01 to 1.04) |
Model 4: model 3 excluding subjects with age ≥65 years.
Model 5: model 3 excluding subjects with history of hypertensive, diabetes mellitus, hyperlipidaemia.
HDLC, high-density lipoprotein cholesterol; LDLC, low-density lipoprotein cholesterol; TC, toal cholesterol; TG, triglyceride.