Table 2

AD use and clinical outcomes at 1-year post-IS discharge

Outcomes at 1 yearCumulative
incidence
UnadjustedWeight adjustedNIHSS weight adjusted
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
All-cause mortality
 AD yes478 (26.05)1.32 (1.21 to 1.45) <0.001 1.29 (1.17 to 1.41) <0.001 1.21 (1.09 to 1.34) <0.001
 AD no4050 (20.28)ReferenceReferenceReference
All-cause readmission
 AD yes940 (52.19)1.22 (1.14 to 1.30) <0.001 1.19 (1.11 to 1.27) <0.001 1.16 (1.08 to 1.24) <0.001
 AD no9008 (46.01)ReferenceReferenceReference
Composite of mortality and all-cause readmission
 AD yes1079 (59.90)1.23 (1.15 to 1.31) <0.001 1.19 (1.12 to 1.27) <0.001 1.16 (1.08 to 1.24) <0.001
 AD no10 274 (52.46)ReferenceReferenceReference
CV readmission
 AD yes440 (24.46)1.10 (1.00 to 1.22)0.0561.11 (1.00 to 1.22)0.051.08 (0.96 to 1.20)0.19
 AD no4496 (22.99)ReferenceReferenceReference
MACE
 AD yes766 (42.61)1.18 (1.10 to 1.27) <0.001 1.17 (1.08 to 1.26) <0.001 1.11 (1.03 to 1.20) 0.009
 AD no7313 (37.40)ReferenceReferenceReference
IS/TIA readmission
 AD yes205 (11.38)1.07 (0.92 to 1.24)0.3891.07 (0.91 to 1.25)0.411.02 (0.86 to 1.21)0.803
 AD No2135 (10.89)ReferenceReferenceReference
ICH readmission
 AD yes19 (1.05)1.19 (0.75 to 1.89)0.4661.07 (0.66 to 1.72)0.7940.99 (0.59 to 1.67)0.975
 AD no178 (0.91)ReferenceReferenceReference
Non-CV readmission
 AD yes694 (38.61)1.27 (1.18 to 1.36) <0.001 1.20 (1.12 to 1.30) <0.001 1.18 (1.08 to 1.28) <0.001
 AD no6370 (32.62)ReferenceReferenceReference
Readmission with depression
 AD yes352 (19.93)3.53 (3.13 to 3.98) <0.001 2.37 (2.09 to 2.70) <0.001 2.31 (2.02 to 2.65) <0.001
 AD no1191 (6.27)ReferenceReferenceReference
Readmission with sepsis
 AD yes218 (12.13)1.46 (1.27 to 1.67) <0.001 1.37 (1.19 to 1.58) <0.001 1.36 (1.16 to 1.59) <0.001
 AD no1703 (8.73)ReferenceReferenceReference
Mean (SD)Difference (95% CI)P valueDifference (95% CI)P valueDifference (95% CI)P value
Home-time, days
 AD yes262.1 (125.8)−24.2 (−29.6 to −18.8) <0.001 −27.6 (−33.0 to −22.1) <0.001 −25.3 (−31.1 to −19.4) <0.001
 AD no284.3 (120.8)ReferenceReferenceReference
  • Bold denotes statistically significant p value < 0.05.

  • AD, antidepressant; CV, cardiovascular; ICH, intracranial haemorrhage; IS, ischaemic stroke; MACE, major adverse cardiac events; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischaemic attack.