Table 1

Summary table

Clot componentStructureInteracts withPotential therapeutic agent(s)
Fibrin (factor Ia)Fibrous proteinPlatelets, factor XIII, RBCsAlteplase, tenecteplase
PlateletsNucleus-free cell fragmentsCollagen, vWF, WBCsGpIIb/IIIa blockers
vWFPlasma glycoproteinFibrin, platelets, collagenADAMTS13, N-acetyle cysteine (NAC)
NETDecondensed DNA/chromatinThrombin, platelets, vWFDNase1
  • NET, neutrophil extracellular trap; RBC, red blood cell; vWF, von Willebrand Factor; WBC, white blood cell.