Aspirin monotherapy | Clopidogrel–aspirin | Other combination | P value* | P1† | P2† | |
Primary outcome | ||||||
Composite of all strokes, MI and all-cause mortality | 16.28 (15.28–17.29) | 13.04 (12.08–14.00) | 15.39 (11.33–19.45) | <0.001 | 1.000 | 0.406 |
Secondary outcome | ||||||
All strokes | 15.12 (14.14–16.09) | 12.15 (11.22–13.08) | 15.26 (11.22–19.31) | <0.001 | 1.000 | 0.191 |
All-cause mortality | 1.82 (1.43–2.21) | 1.37 (1.02–1.73) | 0.18 (0.00–0.69) | 0.037 | 0.078 | 0.234 |
MI | 0.24 (0.10–0.38) | 0.32 (0.15–0.49) | 0.00 (0.00–0.00) | 0.549 | 0.546 | 0.662 |
Ischaemic stroke | 14.88 (13.91–15.85) | 11.90 (10.98–12.83) | 15.22 (11.18–19.27) | <0.001 | 1.000 | 0.151 |
Haemorrhagic stroke | 0.27 (0.12–0.42) | 0.28 (0.12–0.44) | 0.04 (0.00–0.30) | 0.715 | 0.819 | 0.989 |
P1: aspirin monotherapy vs other combination; P2: clopidogrel–aspirin vs other combination.
*P value by the IPTW log-rank test.
†Adjusted p value by the Bonferroni adjustment method.
IPTW, inverse probability of treatment weighting; MI, myocardial infarction.