Table 2

Analyses on the off-hour effect regarding time metrics and clinical outcomes

VariableDefined off-hour with arrival time
(arrival mode)
Adjusted p valueDefined off-hour with puncture time
(puncture mode)
Adjusted p value
Unadjusted ß coefficient/OR (95% CI)Adjusted ß coefficient/OR (95% CI) *Unadjusted ß coefficient/OR (95% CI)Adjusted ß coefficient/OR (95% CI) †
Onset to door time−20.91 (–39.52 to –2.30)−21.56 (–39.96 to –3.16)0.022−3.41 (–22.43 to 15.60)−3.20 (–22.40 to 16.00)0.744
Door to imaging time−0.97 (–4.86 to 2.91)−0.82 (–4.76 to 3.12)0.682−1.51 (–5.46 to 2.44)−1.28 (–5.27 to 2.71)0.529
Door to puncture time6.06 (–7.53 to 19.65)6.95 (–6.70 to 20.60)0.3184.21 (–9.63 to 18.05)2.26 (–11.64 to 16.16)0.749
Puncture to reperfusion2.74 (–6.65 to 12.13)3.50 (–5.88 to 12.87)0.464−3.58 (–13.14 to 5.98)−4.899 (–14.54 to 4.74)0.319
Onset to puncture time−14.85 (–35.30 to 5.60)−14.61 (–35.12 to 5.89)0.1620.80 (–20.06 to 21.65)−0.94 (–21.95 to 20.07)0.930
Onset to reperfusion time−12.21 (–35.20 to 10.78)−11.36 (–34.44 to 11.72)0.334−4.75 (–28.17 to 18.67)−7.75 (–31.36 to 15.86)0.520
Successful reperfusion1.01 (0.67 to 1.51)0.96 (0.63 to 1.46)0.8380.99 (0.65 to 1.50)0.96 (0.63 to 1.47)0.853
Symptomatic ICH1.08 (0.71 to 1.66)1.14 (0.73 to 1.76)0.5691.18 (0.76 to 1.84)1.18 (0.75 to 1.85)0.473
Asymptomatic ICH1.13 (0.81 to 1.57)1.13 (0.80 to 1.59)0.4801.05 (0.75 to 1.47)1.10 (0.78 to 1.55)0.587
Mortality in hospital1.09 (0.76 to 1.56)1.14 (0.78 to 1.67)0.4941.13 (0.78 to 1.65)1.23 (0.82 to 1.86)0.316
90-day mRS score (shift analysis)0.94 (0.71 to 1.22)0.98 (0.74 to 1.29)0.8810.92 (0.70 to 1.21)0.96 (0.72 to 1.28)0.792
Favourable outcome1.01 (0.74 to 1.38)0.96 (0.70 to 1.33)0.8081.04 (0.76 to 1.42)1.00 (0.70 to 1.42)0.994
Mortality at 90 days0.96 (0.68 to 1.36)1.01 (0.70 to 1.46)0.9641.01 (0.71 to 1.45)1.07 (0.72 to 1.59)0.722
  • Reference: patients who presented or get treated during the on-hour period.

  • *Time metrics were adjusted for gender, glucose level, intravenous thrombolysis and local anaesthesia. Other clinical outcomes were adjusted for gender, glucose level, intravenous thrombolysis, local anaesthesia, onset to door time and onset to puncture time.

  • †Time metrics were adjusted for diastolic blood pressure, glucose level, current smoking and baseline National Institute of Health Stroke Scale (NIHSS) score. Other clinical outcomes were adjusted for diastolic blood pressure, glucose level, current smoking, baseline NIHSS score and onset to door time.

  • ICH, intracranial haemorrhage; mRS, modified Rankin Scale.;