Baseline characteristics and 7 day fatality of patients with and without symptomatic infarct swelling
| Symptomatic infarct swelling (n=107) | No symptomatic infarct swelling (n=2854) | P values | |
| Age, years, mean (SD) | 76.8 (12.5) | 77.4 (12.1) | 0.59 |
| Sex, n (%)* | 0.76 | ||
| Male | 50 (3.5) | 1377 (96.5) | |
| Female | 57 (3.7) | 1477 (96.3) | |
| Baseline NIHSS, median (IQR) | 19 (17–23) | 11 (6–17) | <0.001 |
| NIHSS, n (%)* | <0.001 | ||
| NIHSS ≥15 | 88 (8.2) | 983 (91.8) | |
| NIHSS <15 | 19 (1.0) | 1871 (99.0) | |
| Infarct size on pre-randomisation CT, n (%)* | <0.001 | ||
| Large/very large | 55 (11.0) | 443 (89.0) | |
| None/small/medium | 52 (2.1) | 2411 (97.9) | |
| Hyperdense artery sign on prerandomisation CT, n (%)* | <0.001 | ||
| HAS | 63 (8.8) | 653 (91.2) | |
| No HAS | 44 (2.0) | 2201 (98.0) | |
| Allocated treatment, n (%)* | 0.008 | ||
| Alteplase | 67 (4.5) | 1417 (95.5) | |
| Control | 40 (2.7) | 1437 (97.3) | |
| Death in first 7 days, n (%)† | 70 (65.4) | 192 (6.7) | <0.001 |
| Time from onset to randomisation, hours, median (IQR) | 3.5 (2.7–4.2) | 3.9 (2.9–4.9) | 0.14 |
*The proportion of patients with/without infarct swelling in each row characteristic subgroup.
†The proportion of patients who died ≤7 days in patients with/without symptomatic infarct swelling.
HAS, hyperdense artery sign; NIHSS, National Institute of Health Stroke Scale.