Baseline characteristics and outcomes of three time period cohorts
| CNSR-I 2007–2008 (n=13 616) | CNSR-II 2012–2013 (n=21 952) | CNSR-III 2015–2018 (n=15 166) | P for trend* | |
| Demographics | ||||
| Age, median (IQR), y | 67 (56–74) | 65 (56–74) | 63 (54–70) | 0.990 |
| Ethnicity (non-Han) | 460 (3.4) | 669 (3.1) | 440 (2.9) | 0.066 |
| Female sex | 5235 (38.5) | 7949 (36.8) | 4802 (31.7) | <0.001 |
| Medical history | ||||
| Previous stroke/TIA | 4263 (31.3) | 7711 (35.7) | 3675 (24.2) | <0.001 |
| CHD/previous MI | 1961 (14.4) | 2920 (13.5) | 1608 (10.6) | <0.001 |
| Hypertension | 8484 (62.3) | 13 861 (64.2) | 9494 (62.6) | <0.001 |
| Diabetes mellitus | 2831 (20.8) | 4403 (20.4) | 3510 (23.1) | <0.001 |
| Dyslipidaemia | 1552 (11.4) | 2656 (12.3) | 1191 (7.9) | <0.001 |
| Atrial fibrillation | 960 (7.1) | 1467 (6.8) | 1019 (6.7) | 0.505 |
| Onset-to-door time, median (IQR), h | 11.3 (2.9–39.0) | 21.0 (5.0–52.6) | 11.8 (3.1–32.6) | 0.993 |
| NIHSS at admission, median (IQR) | 4 (2–9) | 3 (1–6) | 3 (1–6) | 0.972 |
| In-hospital outcomes | ||||
| mRS ≤2 at discharge | 9508 (70.0) | 16 647 (77.2) | 12 464 (82.4) | <0.001 |
| In-hospital mortality | 355 (2.6) | 223 (1.0) | 35 (0.2) | <0.001 |
| 1 year outcomes | ||||
| MI or vascular death | 1518 (11.2) | 1565 (7.3) | 251 (1.7) | <0.001 |
| MI or non-stroke vascular death | 451 (3.3) | 582 (2.7) | 104 (0.7) | <0.001 |
| MI or all-cause death | 1870 (13.7) | 1945 (9.0) | 563 (3.7) | <0.001 |
| Recurrent Stroke | 2302 (17.8) | 1573 (7.3) | 1473 (9.7) | <0.001 |
| Vascular death | 1378 (10.1) | 1303 (6.0) | 222 (1.5) | <0.001 |
| MI | 180 (1.3) | 298 (1.4) | 39 (0.3) | <0.001 |
Values are presented as n (%) unless otherwise indicated.
*Based on ANOVA.
ANOVA, analysis of variance; CHD, coronary heart disease; CNSR, China National Stroke Registry; MI, myocardial infarction; mRS, modified Rankin scale; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischaemic attack.