Table 1

Baseline demographics by treatment group (GTN/no GTN), in patients with and without headache at day 7

GTN(n=1996)P valueNo GTN(n=2004)P value
HeadacheYesNoYesNo
No of patients (n)360 (18.0)1636 (82.0)170 (8.5)1834 (91.5)
Age (years)66.6 (12.4)71.1 (11.9)<0.00567.6 (11.8)70.6 (12.2)0.002
Sex, female (%)172 (47.8)679 (41.5)0.02982 (48.2)777 (42.4)0.14
Pre-morbid mRS score0 (1)0 (0)0.0060 (0)0 (1)0.12
Medical history (%)
 Hypertension220 (61.1)1065 (65.1)0.15105 (61.8)1211 (66)0.26
 Stroke51 (14.2)262 (16)0.3822 (12.9)255 (13.9)0.73
 Diabetes mellitus52 (14.4)289 (17.7)0.1429 (17.1)324 (17.7)0.84
 Current nitrate use18 (5)69 (4.2)0.516 (3.5)61 (3.3)0.89
Onset to randomisation (hours)25.2 (12.5)25.8 (12.9)0.4225.1 (12.5)26.3 (12.9)0.25
Haemodynamics
 Systolic BP (mm Hg)166.7 (18.5)167.5 (18.8)0.46168.4 (19.5)167 (19.1)0.36
 Diastolic BP (mm Hg)91.6 (12.7)89.3 (13)0.00289.2 (12.5)89.4 (13.4)0.88
 Heart rate, mean (bpm)78.2 (14.8)77.5 (14.8)0.4577.6 (14.3)77.3 (14.7)0.77
 Atrial fibrillation (%)53 (14.7)336 (20.5)0.01233 (19.4)338 (18.4)0.75
Syndrome
 TACS (%)86 (23.9)527 (32.2)0.00258 (34.1)535 (29.2)0.18
 LACS (%)154 (42.8)541 (33.1)0.00848 (28.2)653 (35.6)0.28
Dysphasia90 (25.0)704 (43.0)<0.00559 (34.7)750 (40.9)0.12
Neglect/inattention91 (26.6)431 (30)0.2161 (40.7)485 (29.6)0.005
Hemianopia74 (20.6)297 (18.2)0.8951 (30)313 (17.1)<0.005
SSS score (/58)37.2 (11.2)33.2 (13.4)<0.00533.8 (11.9)33.5 (13.4)0.70
Stroke type (%)
 Ischaemic287 (79.7)1373 (83.9)0.043129 (75.9)1544 (84.2)0.12
 Haemorrhage39 (10.8)278 (17)66 (38.8)244 (13.3)
 Non stroke2 (0.6)11 (0.7)7 (4.1)19 (1)
Lesion side (%)
 Left109 (45.0)501 (47)0.7849 (43)541 (45.3)0.50
 Right131 (54.1)554 (51.9)63 (55.3)645 (54)
 Both2 (0.8)12 (1.1)2 (1.8)9 (0.8)
Feeding status, non-oral (%)76 (21.1)591 (36.1)<0.00556 (32.9)605 (33)0.99
Neuroimaging adjudication
 White matter change (%)116 (32.2)701 (42.8)<0.00564 (37.6)763 (41.6)0.16
 White matter score (/4)0 (2)0 (2)<0.0050 (2)0 (2)0.18
 Atrophy (%)272 (75.6)1354 (82.8)<0.005135 (79.4)1464 (79.8)0.24
 Atrophy score (/4)2 (1)2 (2)<0.0052 (1)2 (2)0.007
 Previous stroke lesion (%)194 (53.9)992 (60.6)0.00681 (47.6)1056 (57.6)0.002
Alteplase36 (10.1)167 (10.2)0.9325 (14.9)195 (10.7)0.095
Continued antihypertensives (%)81 (22.5)432 (26.4)0.00938 (22.4)486 (26.5)0.26
  • Data are number (%), median (IQR) or mean (SD). Comparison by χ2, Kruskal-Wallis or independent t-test.

  • BP, blood pressure; GTN, glyceryl trinitrate; LACS, lacunar syndrome; mRS, modified Rankin Scale; SSS, Scandinavian Stroke Scale; TACS, total anterior circulation syndrome.