Table 2

Association of all-cause death and poor functional outcomes with quintiles of CO2CP

OutcomesQuintile of CO2CPP for trend
Q1Q2Q3Q4Q5
At 3 months
Death39 (2.04)27 (1.38)21 (1.12)16 (0.86)23 (1.20)
 Unadjusted2.55 (1.37–4.78)1.77 (0.94–3.33)1.40 (0.73–2.72)Reference1.24 (0.64–2.39)0.7585
 Model 12.65 (1.41–4.96)1.70 (0.89–3.22)1.41 (0.73–2.75)Reference1.16 (0.60–2.27)0.6639
 Model 22.33 (1.23–4.44)1.63 (0.85–3.13)1.24 (0.62–2.46)Reference1.15 (0.58–2.27)0.7527
 Model 32.40 (1.27–4.55)1.58 (0.82–3.03)1.16 (0.58–2.32)Reference1.29 (0.64–2.57)0.8246
mRS 3–6319 (16.67)276 (14.11)257 (13.71)208 (11.13)228 (11.89)
 Unadjusted1.74 (1.41–2.14)1.39 (1.13–1.70)1.30 (1.06–1.59)Reference1.05 (0.85–1.29)0.5259
 Model 11.80 (1.46–2.22)1.40 (1.14–1.72)1.34 (1.09–1.65)Reference1.02 (0.83–1.26)0.3626
 Model 21.57 (1.25–1.97)1.27 (1.01–1.58)1.25 (1.00–1.57)Reference0.96 (0.76–1.21)0.3243
 Model 31.58 (1.26–1.98)1.27 (1.02–1.59)1.27 (1.01–1.59)Reference0.97 (0.77–1.23)0.3814
mRS 2–6561 (29.31)516 (26.38)483 (25.77)448 (23.97)476 (24.82)
 Unadjusted1.41 (1.20–1.66)1.18 (1.01–1.38)1.11 (0.95–1.30)Reference1.07 (0.91–1.25)0.5389
 Model 11.46 (1.24–1.72)1.19 (1.02–1.40)1.14 (0.97–1.34)Reference1.05 (0.90–1.24)0.3668
 Model 21.26 (1.05–1.51)1.09 (0.92–1.30)1.07 (0.90–1.28)Reference1.02 (0.85–1.21)0.4684
 Model 31.26 (1.05–1.51)1.10 (0.92–1.30)1.08 (0.91–1.28)Reference1.02 (0.86–1.22)0.4954
At 1 year
Death70 (3.66)60 (3.07)58 (3.09)41 (2.19)51 (2.66)
 Unadjusted1.64 (1.08–2.48)1.41 (0.94–2.12)1.42 (0.95–2.14)Reference1.11 (0.72–1.70)0.7947
 Model 11.68 (1.11–2.54)1.40 (0.93–2.11)1.48 (0.98–2.22)Reference1.05 (0.68–1.62)0.9283
 Model 21.50 (0.99–2.28)1.35 (0.89–2.04)1.34 (0.89–2.03)Reference1.00 (0.65–1.55)0.9980
 Model 31.56 (1.03–2.36)1.35 (0.89–2.04)1.35 (0.89–2.04)Reference1.06 (0.68–1.65)0.8666
mRS 3–6301 (15.73)243 (12.42)246 (13.13)212 (11.34)233 (12.15)
 Unadjusted1.44 (1.17–1.77)1.11 (0.91–1.37)1.16 (0.95–1.42)Reference1.05 (0.86–1.30)0.6571
 Model 11.50 (1.21–1.85)1.12 (0.91–1.38)1.21 (0.98–1.49)Reference1.03 (0.83–1.27)0.4322
 Model 21.32 (1.05–1.66)1.01 (0.81–1.27)1.11 (0.88–1.38)Reference0.97 (0.77–1.22)0.3000
 Model 31.33 (1.06–1.67)1.01 (0.81–1.27)1.12 (0.89–1.41)Reference0.98 (0.78–1.24)0.3659
mRS 2–6520 (27.17)472 (24.13)455 (24.28)401 (21.46)441 (22.99)
 Unadjusted1.47 (1.24–1.73)1.21 (1.03–1.43)1.18 (1.01–1.38)Reference1.09 (0.93–1.29)0.9855
 Model 11.53 (1.30–1.81)1.23 (1.05–1.45)1.22 (1.04–1.44)Reference1.07 (0.91–1.27)0.7330
 Model 21.35 (1.13–1.62)1.14 (0.96–1.36)1.16 (0.97–1.38)Reference1.04 (0.87–1.25)0.8040
 Model 31.36 (1.13–1.62)1.14 (0.96–1.36)1.17 (0.98–1.39)Reference1.05 (0.88–1.25)0.8458
  • Model 1: adjusted for age and gender.

  • Model 2: adjusted for age, gender, body mass index, history of dyslipidaemia, stroke or transient ischaemic stroke, atrial fibrillation/flutter, stroke type, current smoker, antihypertensive agents, anticoagulant agents, National Institutes of Health Stroke Scale score and high-density lipoprotein cholesterol on admission.

  • Model 3: adjusted for variables in model 2, plus history of chronic obstructive pulmonary disease, time from onset of symptoms to admission and high-sensitivity C reactive protein on admission.

  • CO2CP, carbon dioxide combining power; mRS, modified Rankin Scale.