Association of all-cause death and poor functional outcomes with quintiles of CO2CP
| Outcomes | Quintile of CO2CP | P for trend | ||||
| Q1 | Q2 | Q3 | Q4 | Q5 | ||
| At 3 months | ||||||
| Death | 39 (2.04) | 27 (1.38) | 21 (1.12) | 16 (0.86) | 23 (1.20) | |
| Unadjusted | 2.55 (1.37–4.78) | 1.77 (0.94–3.33) | 1.40 (0.73–2.72) | Reference | 1.24 (0.64–2.39) | 0.7585 |
| Model 1 | 2.65 (1.41–4.96) | 1.70 (0.89–3.22) | 1.41 (0.73–2.75) | Reference | 1.16 (0.60–2.27) | 0.6639 |
| Model 2 | 2.33 (1.23–4.44) | 1.63 (0.85–3.13) | 1.24 (0.62–2.46) | Reference | 1.15 (0.58–2.27) | 0.7527 |
| Model 3 | 2.40 (1.27–4.55) | 1.58 (0.82–3.03) | 1.16 (0.58–2.32) | Reference | 1.29 (0.64–2.57) | 0.8246 |
| mRS 3–6 | 319 (16.67) | 276 (14.11) | 257 (13.71) | 208 (11.13) | 228 (11.89) | |
| Unadjusted | 1.74 (1.41–2.14) | 1.39 (1.13–1.70) | 1.30 (1.06–1.59) | Reference | 1.05 (0.85–1.29) | 0.5259 |
| Model 1 | 1.80 (1.46–2.22) | 1.40 (1.14–1.72) | 1.34 (1.09–1.65) | Reference | 1.02 (0.83–1.26) | 0.3626 |
| Model 2 | 1.57 (1.25–1.97) | 1.27 (1.01–1.58) | 1.25 (1.00–1.57) | Reference | 0.96 (0.76–1.21) | 0.3243 |
| Model 3 | 1.58 (1.26–1.98) | 1.27 (1.02–1.59) | 1.27 (1.01–1.59) | Reference | 0.97 (0.77–1.23) | 0.3814 |
| mRS 2–6 | 561 (29.31) | 516 (26.38) | 483 (25.77) | 448 (23.97) | 476 (24.82) | |
| Unadjusted | 1.41 (1.20–1.66) | 1.18 (1.01–1.38) | 1.11 (0.95–1.30) | Reference | 1.07 (0.91–1.25) | 0.5389 |
| Model 1 | 1.46 (1.24–1.72) | 1.19 (1.02–1.40) | 1.14 (0.97–1.34) | Reference | 1.05 (0.90–1.24) | 0.3668 |
| Model 2 | 1.26 (1.05–1.51) | 1.09 (0.92–1.30) | 1.07 (0.90–1.28) | Reference | 1.02 (0.85–1.21) | 0.4684 |
| Model 3 | 1.26 (1.05–1.51) | 1.10 (0.92–1.30) | 1.08 (0.91–1.28) | Reference | 1.02 (0.86–1.22) | 0.4954 |
| At 1 year | ||||||
| Death | 70 (3.66) | 60 (3.07) | 58 (3.09) | 41 (2.19) | 51 (2.66) | |
| Unadjusted | 1.64 (1.08–2.48) | 1.41 (0.94–2.12) | 1.42 (0.95–2.14) | Reference | 1.11 (0.72–1.70) | 0.7947 |
| Model 1 | 1.68 (1.11–2.54) | 1.40 (0.93–2.11) | 1.48 (0.98–2.22) | Reference | 1.05 (0.68–1.62) | 0.9283 |
| Model 2 | 1.50 (0.99–2.28) | 1.35 (0.89–2.04) | 1.34 (0.89–2.03) | Reference | 1.00 (0.65–1.55) | 0.9980 |
| Model 3 | 1.56 (1.03–2.36) | 1.35 (0.89–2.04) | 1.35 (0.89–2.04) | Reference | 1.06 (0.68–1.65) | 0.8666 |
| mRS 3–6 | 301 (15.73) | 243 (12.42) | 246 (13.13) | 212 (11.34) | 233 (12.15) | |
| Unadjusted | 1.44 (1.17–1.77) | 1.11 (0.91–1.37) | 1.16 (0.95–1.42) | Reference | 1.05 (0.86–1.30) | 0.6571 |
| Model 1 | 1.50 (1.21–1.85) | 1.12 (0.91–1.38) | 1.21 (0.98–1.49) | Reference | 1.03 (0.83–1.27) | 0.4322 |
| Model 2 | 1.32 (1.05–1.66) | 1.01 (0.81–1.27) | 1.11 (0.88–1.38) | Reference | 0.97 (0.77–1.22) | 0.3000 |
| Model 3 | 1.33 (1.06–1.67) | 1.01 (0.81–1.27) | 1.12 (0.89–1.41) | Reference | 0.98 (0.78–1.24) | 0.3659 |
| mRS 2–6 | 520 (27.17) | 472 (24.13) | 455 (24.28) | 401 (21.46) | 441 (22.99) | |
| Unadjusted | 1.47 (1.24–1.73) | 1.21 (1.03–1.43) | 1.18 (1.01–1.38) | Reference | 1.09 (0.93–1.29) | 0.9855 |
| Model 1 | 1.53 (1.30–1.81) | 1.23 (1.05–1.45) | 1.22 (1.04–1.44) | Reference | 1.07 (0.91–1.27) | 0.7330 |
| Model 2 | 1.35 (1.13–1.62) | 1.14 (0.96–1.36) | 1.16 (0.97–1.38) | Reference | 1.04 (0.87–1.25) | 0.8040 |
| Model 3 | 1.36 (1.13–1.62) | 1.14 (0.96–1.36) | 1.17 (0.98–1.39) | Reference | 1.05 (0.88–1.25) | 0.8458 |
Model 1: adjusted for age and gender.
Model 2: adjusted for age, gender, body mass index, history of dyslipidaemia, stroke or transient ischaemic stroke, atrial fibrillation/flutter, stroke type, current smoker, antihypertensive agents, anticoagulant agents, National Institutes of Health Stroke Scale score and high-density lipoprotein cholesterol on admission.
Model 3: adjusted for variables in model 2, plus history of chronic obstructive pulmonary disease, time from onset of symptoms to admission and high-sensitivity C reactive protein on admission.
CO2CP, carbon dioxide combining power; mRS, modified Rankin Scale.