Baseline characteristics of the included patients in the patients who underwent whole genome sequencing and the rest of the patients in CNSR-III
| Characteristics | Included (n=10 914 to 72.0%) | Excluded (n=4252 to 28.0%) | Total (n=15 166 to 100%) |
| Age (years), mean±SD | 62.2±11.3 | 62.2±11.3 | 62.2±11.3 |
| Female, n (%) | 3429 (31.4) | 1373 (32.3) | 4802 (31.7) |
| Ethnicity (non-Han), n (%) | 306 (2.8) | 134 (3.2) | 440 (2.9) |
| Stroke type | |||
| IS | 10 166 (93.2) | 3980 (93.6) | 14 146 (93.3) |
| TIA | 748 (6.8) | 272 (6.4) | 1020 (6.7) |
| Current smoker, n (%) | 3472 (31.8) | 1280 (30.1) | 4752 (31.3) |
| Heavy drinker, n (%)* | 1582 (14.5) | 544 (12.8) | 2126 (14.0) |
| Medical history, n (%) | |||
| Ischaemic stroke | 2322 (21.3) | 827 (19.4) | 3149 (20.8) |
| Coronary heart disease | 1179 (10.8) | 429 (10.1) | 1608 (10.6) |
| Atrial fibrillation | 765 (7.0) | 254 (6.0) | 1019 (6.7) |
| Hypertension | 6858 (62.8) | 2636 (62.0) | 9494 (62.6) |
| Diabetes mellitus | 2609 (23.9) | 901 (21.2) | 3510 (23.1) |
| Hypercholesterolaemia | 903 (8.3) | 288 (6.8) | 1191 (7.9) |
| NIHSS at admission, median (IQR)† | 3.0 (1.0 to 6.0) | 3.0 (1.0 to 5.0) | 3.0 (1.0 to 6.0) |
| NIHSS 0–3 | 5120 (50.4) | 2199 (55.2) | 7319 (51.7) |
| NIHSS ≥4 | 5046 (49.6) | 1781 (44.8) | 6827 (48.3) |
*Heavy drinker was defined as ≥2 standard alcohol consumption per day.
†NIHSS in this table were summarised among IS patients only.
CNSR-III, the Third China National Stroke Registry; IS, ischaemic stroke; NIHSS, National Institutes of Health Stroke Scale score; TIA, transient ischaemic attack.