Table 2

Predictors of 3-month excellent outcome after IVT

	3-month mRS score 0–1 (n=77/247)
	Bivariate (n=247)			Multivariate (n=247)
	OR	95% CI	P value	OR	95% CI	P value
Sociodemographics features
Age	0.99	0.97 to 1.01	0.36
Sex: male versus female	0.62	0.36 to 1.07	0.09
Comorbidities and risk factors
Hypertension: absence versus presence	1.87	1.42 to 2.47	0.024	2.43	1.74 to 3.38	0.0074
Diabetes: absence versus presence	1.83	0.80 to 4.22	0.15
Current smoking: absence versus presence	1.86	1.30 to 2.66	0.083	2.76	1.79 to 4.26	0.019
Baseline clinical examination
NIHSS score, pts*	0.90	0.84 to 0.96	0.0018
Systolic blood pressure, mm Hg*	1.00	0.99 to 1.01	0.91
Glycaemia, g/L*	0.39	0.17 to 0.92	0.031
Temperature, °C*	1.23	0.74 to 2.05	0.43
OTT
Hour*	0.53	0.35 to 0.83	0.0048	0.47	0.23 to 0.78	0.0033
Imaging features
Imaging technique: CT versus MRI	0.64	0.32 to 1.25	0.19
DWI volume, 10 mL†‡	0.85	0.77 to 0.94	0.0016	0.78	0.68 to 0.89	0.0004
Infarct territory			0.0033
Superficial MCA	Reference
Deep MCA	0.86	0.35 to 2.08	0.73
Superficial and deep MCA	0.34	0.14 to 0.81	0.015
Other	0.41	0.07 to 2.23	0.30
Thrombus length‡
HMCAS length, mm*	0.95	0.91 to 1.00	0.030	0.98	0.92 to 1.03	0.37
SVS length, mm*	0.96	0.93 to 0.99	0.017	0.87	0.80 to 0.94	0.0012
Occlusion site: M1 versus C1	4.66	1.61 to 13.52	0.0046
Clot burden score‡
CT, pts*	1.23	1.00 to 1.50	0.046
MRI, pts*	1.26	1.07 to 1.47	0.0053
HMCAS/SVS
HMCAS: presence versus absence	0.87	0.25 to 2.99	0.83	0.80	0.22 to 2.99	0.74
SVS: presence versus absence	0.84	0.40 to 1.77	0.65	7.89	1.65 to 37.78	0.0097
FVH/DWI mismatch: yes versus no‡	2.71	1.19 to 6.20	0.018
ASPECT-FVH score, pts*‡	1.09	0.93 to 1.27	0.31
DWM Fazekas score, pts‡
CT, pts*	0.68	<0.01 to >100	0.99
MRI, pts*	0.79	0.56 to 1.10	0.16

3-month excellent outcome after IVT defined by a 3-month mRS score ≤1.
All ORs are calculated for 3-month mRS score ≤2.
Bold values shows p<0.05.
*ORs express the risk variation for a unit increase of the variable.
†ORs express the risk variation for 10 mL increase in the ischaemic core volume on DWI.
‡Nested effect is adjusted on the nesting characteristics, that is, imaging type, to consider effect differently in CT and in MRI.
ASPECTS-FVH score, Alberta Stroke Programme Early CT score and extent of FLAIR vascular hyperintensities (0–6); C1, distal internal carotid artery; clot burden score (0–10); DWI, diffusion-weighted imaging; DWI volume, ischaemic core volume on DWI; DWM Fazekas score, deep white matter Fazekas score (0–3); FVH/DWI mismatch, FLAIR vascular hyperintensity and DWI infarct hyperintensity mismatch; HMCAS/SVS, hyper-dense MCA sign on CT or susceptibility vessel sign on T2*-MRI; IVT, intravenous thrombolysis; M1, first segment of MCA; MCA, middle cerebral artery; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke scale; OTT, onset-to-treatment time; pts, patients.