Outcomes | Event (%) | Unadjusted model | Adjusted model* | Adjusted model† | ||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||
Recurrent stroke | Non-stenosis‡ | 11 (2.4) | REF | REF | REF | REF | REF | REF |
ICAS only | 13 (5.6) | 2.54 (1.14 to 5.67) | 0.023 | 2.51 (1.12 to 5.60) | 0.025 | 2.16 (0.95 to 4.92) | 0.066 | |
ECAS only | 3 (5.9) | 2.69 (0.75 to 9.65) | 0.129 | 2.51 (0.70 to 9.04) | 0.159 | 2.70 (0.74 to 9.82) | 0.132 | |
ICAS+ECAS | 5 (8.5) | 4.06 (1.41 to 11.68) | <0.001 | 3.86 (1.34 to 11.14) | 0.013 | 3.40 (1.15 to 10.04) | 0.027 | |
Composite vascular events | Non-stenosis‡ | 14 (3.0) | REF | REF | REF | REF | REF | REF |
ICAS only | 13 (5.6) | 2.00 (0.94 to 4.26) | 0.072 | 2.00 (0.94 to 4.26) | 0.072 | 1.73 (0.80 to 3.75) | 0.166 | |
ECAS only | 3 (5.9) | 2.12 (0.61 to 7.38) | 0.237 | 2.06 (0.59 to 7.21) | 0.257 | 2.22 (0.63 to 7.85) | 0.215 | |
ICAS+ECAS | 7 (11.9) | 4.44 (1.79 to 11.01) | 0.001 | 4.41 (1.77 to 10.97) | 0.001 | 3.82 (1.50 to 9.72) | 0.005 |
*Multivariate Cox regression model adjusted for age and sex.
†Multivariate Cox regression model adjusted for age, sex, mRS prior to the current event, history of ischaemic stroke and history of hypertension.
‡Indicated as reference.
ECAS, extracranial atherosclerotic stenosis; ICAS, intracranial atherosclerotic stenosis; mRS, modified Rankin Scale; REF, as reference.