Table 2

One-year outcomes stratified by severity and location of atherosclerosis

OutcomesEvent (%)Unadjusted modelAdjusted model*Adjusted model†
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
Recurrent strokeNon-stenosis‡11 (2.4)REFREFREFREFREFREF
ICAS only13 (5.6)2.54 (1.14 to 5.67)0.0232.51 (1.12 to 5.60)0.0252.16 (0.95 to 4.92)0.066
ECAS only3 (5.9)2.69 (0.75 to 9.65)0.1292.51 (0.70 to 9.04)0.1592.70 (0.74 to 9.82)0.132
ICAS+ECAS5 (8.5)4.06 (1.41 to 11.68)<0.0013.86 (1.34 to 11.14)0.0133.40 (1.15 to 10.04)0.027
Composite vascular eventsNon-stenosis‡14 (3.0)REFREFREFREFREFREF
ICAS only13 (5.6)2.00 (0.94 to 4.26)0.0722.00 (0.94 to 4.26)0.0721.73 (0.80 to 3.75)0.166
ECAS only3 (5.9)2.12 (0.61 to 7.38)0.2372.06 (0.59 to 7.21)0.2572.22 (0.63 to 7.85)0.215
ICAS+ECAS7 (11.9)4.44 (1.79 to 11.01)0.0014.41 (1.77 to 10.97)0.0013.82 (1.50 to 9.72)0.005
  • *Multivariate Cox regression model adjusted for age and sex.

  • †Multivariate Cox regression model adjusted for age, sex, mRS prior to the current event, history of ischaemic stroke and history of hypertension.

  • ‡Indicated as reference.

  • ECAS, extracranial atherosclerotic stenosis; ICAS, intracranial atherosclerotic stenosis; mRS, modified Rankin Scale; REF, as reference.