Interaction with poor functional outcome after intravenous thrombolysis in women versus men
| Women n (%) | Men n (%) | mRS score of 3–6 unadjusted OR (95% CI) | P value | Interaction p values | mRS score of 3–6 adjusted OR (95% CI) * | P value | Interaction p values | |
| Age<50 years | 17 (34.7) | 31 (22.3) | 1.85 (0.91 to 3.77) | 0.09 | 0.40 | 1.57 (0.52 to 4.76) | 0.42 | 0.53 |
| Age≥50 years | 226 (47.1) | 296 (39.9) | 1.34 (1.06 to 1.69) | 0.01 | 1.00 (0.74 to 1.37) | 0.98 | ||
| Pre-mRS≤2 | 238 (46.1) | 319 (36.8) | 1.47 (1.18 to 1.83) | 0.0007 | 0.21 | 1.02 (0.75 to 1.39) | 0.89 | 0.56 |
| Pre-mRS>2 | 5 (41.7) | 7 (58.3) | 0.51 (0.10 to 2.59) | 0.42 | – | – | ||
| NIHSS≤5 | 11 (13.4) | 14 (9.2) | 1.53 (0.66 to 3.54) | 0.32 | 0.89 | 0.83 (0.26 to 2.68) | 0.75 | 0.97 |
| NIHSS>5 | 232 (51.9) | 313 (42.9) | 1.43 (1.13 to 1.82) | 0.003 | 1.05 (0.78 to 1.41) | 0.76 | ||
| TOAST types | 0.54 | 0.48 | ||||||
| LAA | 123 (46.2) | 214 (40.0) | 1.30 (0.97 to 1.75) | 0.08 | 0.95 (0.63 to 1.42) | 0.8 | ||
| SAO | 10 (22.7) | 15 (18.5) | 1.29 (0.53 to 3.19) | 0.57 | 0.19 (0.04 to 0.95) | 0.04 | ||
| CE | 81 (57.9) | 62 (53.5) | 1.20 (0.73 to 1.96) | 0.48 | 1.14 (0.6 to 2.19) | 0.68 | ||
| Others | 28 (36.8) | 30 (21.9) | 2.08 (1.12 to 3.86) | 0.02 | 1.47 (0.61 to 3.55) | 0.39 |
*Adjusted baseline variables: age, diastolic blood pressure, current smoking, hypertension, diabetes mellitus, atrial fibrillation, antihypertensive agents before stroke, stroke-to-needle time, stroke-to-visit time, stroke-to-imaging time, National Institute of Health Stroke Scale (NIHSS) on admission and Trial of Org 10172 in Acute Stroke Treatment (TOAST) types, except the analysis factor itself.
CE, cardioembolism; LAA, large-artery atherosclerosis; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; SAO, small-artery occlusion; TOAST, the Trial of Org 10172 in Acute Stroke Treatment.