Table 4

Logistic regression model for factors related with poor clinical outcome at 3 months

	Unadjusted			Adjusted*
	OR	95% CI	P value	OR	95% CI	P value
sTWEAK ≥5600 pg/mL	3.12	2.13 to 4.55	<0.0001	1.57	0.87 to 2.83	0.129
ICH basal volume	1.03	1.03 to 1.04	<0.0001	1.04	1.03 to 1.05	<0.0001
Leukoaraiosis	4.16	2.92 to 5.86	<0.0001	4.31	2.89 to 6.42	<0.0001
ICH growth	1.87	1.29 to 2.71	0.001	1.61	0.88 to 2.94	0.123
sTWEAK×ICH growth				2.23	1.40 to 3.55	0.001

	Unadjusted			Adjusted†
	OR	95% CI	P value	OR	95% CI	P value
sTWEAK ≥5600 pg/mL	3.12	2.13 to 4.55	<0.0001	1.67	0.93 to 2.99	0.086
ICH basal volume	1.03	1.03 to 1.04	<0.0001	1.03	1.03 to 1.04	<0.0001
Leukoaraiosis
No LA	Ref.	–	–	Ref	–	–
Grade I	1.43	1.06 to 1.92	0.019	2.63	1.66 to 4.14	<0.0001
Grade II	2.47	1.79 to 3.39	<0.0001	6.05	3.67 to 9.98	<0.0001
Grade III	3.07	1.89 to 4.97	<0.0001	17.03	5.72 to 50.68	<0.0001
ICH growth	1.87	1.29 to 2.71	0.001	1.49	0.82 to 2.73	0.193
sTWEAK×ICH growth				2.01	1.27 to 3.23	0.003

*Adjusted by age, previous mRS, atrial fibrillation, previous anticoagulants, temperature at admission, glucose, leucocytes, C reactive protein, LDL cholesterol, sedimentation rate, basal ICH volume, presence of LA, ICH growth and sTWEAK ≥5600 pg/mL.
†Adjusted by the same variables; the presence of LA was replaced by the three grades of LA.
HDL, High Density Lipoprotein; ICH, intracerebral haemorrhage; LA, leukoaraiosis; LDL, Low Density Lipoprotein; mRS, modified Rankin Scale; sTWEAK, soluble tumour necrosis factor-like weak inducer of apoptosis.