Table 2

ORs for newly developed carotid plaque for various level of lipid burdens in sensitivity analysis

Newly developed carotid plaqueNewly developed vulnerable carotid plaque
Model 4 (95% CI)Model 5 (95% CI)Model 4 (95% CI)Model 5 (95% CI)
TC burden
 Q11.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 Q21.12 (0.87 to 1.44)1.09 (0.84 to 1.41)1.12 (0.88 to 1.42)1.08 (0.85 to 1.37)
 Q31.31 (1.01 to 1.68)1.30 (1.00 to 1.68)1.31 (1.03 to 1.67)1.28 (1.01 to 1.63)
 Q41.67 (1.29 to 2.15)1.54 (1.18 to 2.00)1.68 (1.32 to 2.14)1.49 (1.17 to 1.89)
 P for trend<0.0010.003<0.001<0.001
 Continuous scale1.03 (1.01 to 1.05)1.03 (1.01 to 1.04)1.03 (1.02 to 1.05)1.03 (1.01 to 1.04)
TG burden
 Q11.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 Q21.04 (0.81 to 1.35)1.05 (0.81 to 1.37)1.05 (0.82 to 1.34)1.03 (0.82 to 1.31)
 Q31.09 (0.84 to 1.43)1.15 (0.88 to 1.49)1.09 (0.85 to 1.40)1.14 (0.90 to 1.45)
 Q41.65 (1.26 to 2.16)1.64 (1.24 to 2.16)1.56 (1.21 to 2.01)1.51 (1.18 to 1.95)
 P for trend0.0200.0170.0150.010
 Continuous scale1.01 (1.00 to 1.03)1.02 (1.00 to 1.03)1.01 (1.00 to 1.02)1.02 (1.00 to 1.03)
HDLC burden
 Q11.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 Q21.16 (0.90 to 1.48)1.20 (0.92 to 1.56)1.21 (0.95 to 1.54)1.23 (0.97 to 1.57)
 Q30.96 (0.74 to 1.24)1.01 (0.77 to 1.32)1.03 (0.81 to 1.31)1.09 (0.85 to 1.39)
 Q41.09 (0.84 to 1.41)1.17 (0.89 to 1.53)1.12 (0.87 to 1.43)1.17 (0.91 to 1.50)
 P for trend0.4540.1660.4330.182
 Continuous scale1.02 (0.97 to 1.07)1.04 (0.99 to 1.09)1.02 (0.97 to 1.07)1.03 (0.99 to 1.08)
LDLC burden
 Q11.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 Q20.98 (0.76 to 1.26)1.04 (0.80 to 1.35)1.03 (0.81 to 1.31)1.10 (0.87 to 1.40)
 Q30.98 (0.77 to 1.26)0.94 (0.73 to 1.23)1.02 (0.80 to 1.29)1.04 (0.82 to 1.33)
 Q41.20 (0.93 to 1.54)1.30 (1.00 to 1.69)1.19 (0.94 to 1.51)1.31 (1.03 to 1.67)
 P for trend0.0160.0060.0090.001
 Continuous scale1.03 (1.01 to 1.05)1.04 (1.01 to 1.06)1.03 (1.01 to 1.05)1.04 (1.01 to 1.06)
Non-HDLC burden
 Q11.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
 Q21.21 (0.94 to 1.56)1.12 (0.87 to 1.45)1.26 (0.99 to 1.60)1.17 (0.92 to 1.48)
 Q31.18 (0.91 to 1.52)1.15 (0.88 to 1.49)1.21 (0.95 to 1.55)1.16 (0.91 to 1.47)
 Q41.56 (1.20 to 2.03)1.53 (1.17 to 2.01)1.60 (1.24 to 2.05)1.53 (1.20 to 1.96)
 P for trend0.0050.008<0.001<0.001
 Continuous scale1.02 (1.01 to 1.04)1.02 (1.01 to 1.04)1.02 (1.01 to 1.04)1.03 (1.01 to 1.04)
  • Model 4: model 3 excluding subjects with age ≥65 years.

  • Model 5: model 3 excluding subjects with history of hypertensive, diabetes mellitus, hyperlipidaemia.

  • HDLC, high-density lipoprotein cholesterol; LDLC, low-density lipoprotein cholesterol; TC, toal cholesterol; TG, triglyceride.