Table 1

Multivariate analysis of potential causes of inconsistency between individualised aetiological classification and centralised classification of the study population

CharacteristicsCentrally reassigned LAANewly diagnosed LAA
VariablesConsistent LAA as referenceAdjusted OR (95% CI)P valueAdjusted OR (95% CI)P value
Medical history
 Ischaemic strokeYes0.841 (0.749 to 0.943)0.0030.843 (0.687 to 1.035)0.103
 TIAYes0.606 (0.451 to 0.815)<0.0010.585 (0.333 to 1.028)0.062
 DyslipidaemiaYes0.822 (0.689 to 0.980)0.0290.806 (0.587 to 1.106)0.181
Baseline NIHSS score0–31.000 (ref)Ref1.000 (ref)Ref
≥40.731 (0.663 to 0.806)<0.00010.537 (0.453 to 0.636)<0.0001
Inpatient departmentStroke unit1.000 (ref)Ref1.000 (ref)Ref
Other1.140 (1.012 to 1.284)0.0311.037 (0.843 to 1.274)0.733
Geographical regionWest1.000 (ref)Ref1.000 (ref)Ref
Middle0.941 (0.770 to 1.150)0.5510.445 (0.330 to 0.600)<0.0001
East0.882 (0.726 to 1.072)0.2070.476 (0.359 to 0.631)<0.0001
AreaRural1.000 (ref)Ref1.000 (ref)Ref
Urban0.792 (0.687 to 0.913)0.0011.163 (0.911 to 1.484)0.226
Hospital typeSecondary1.000 (ref)Ref1.000 (ref)Ref
Tertiary0.748 (0.627 to 0.891)0.0010.796 (0.591 to 1.072)0.133
P value of interaction for area and hospital type0.0050.214
Variables Consistent CE as reference Centrally reassigned CE Newly diagnosed CE
Adjusted OR (95% CI) P value Adjusted OR (95% CI) P value
Medical history
 Known atrial fibrillation or flutterYes0.122 (0.070 to 0.213)<0.00010.086 (0.053 to 0.140)<0.0001
 Diabetes mellitusYes1.015 (0.599 to 1.721)0.9551.667 (1.060 to 2.623)0.027
Baseline NIHSS score0–31.000 (ref)Ref1.000 (ref)Ref
≥41.658 (1.131 to 2.432)0.0100.759 (0.541 to 1.065)0.110
Evaluation of cardiac rhythm
 HolterYes1.077 (0.606 to 1.915)0.8000.567 (0.350 to 0.919)0.021
Variables Consistent SVO as reference Centrally reassigned SVO Newly diagnosed SVO
Adjusted OR (95% CI) P value Adjusted OR (95% CI) P value
Age1.010 (1.003 to 1.018)0.0041.011 (1.003 to 1.019)0.005
Sex0.970 (0.813 to 1.158)0.7380.741 (0.613 to 0.896)0.002
mRS prior to current event1.072 (0.966 to 1.191)0.1921.215 (1.091 to 1.354)<0.001
Medical history
 Current or previous smokerYes0.780 (0.655 to 0.929)0.0050.858 (0.716 to 1.028)0.096
 Baseline NIHSS score0–31.000 (ref)Ref1.000 (ref)Ref
≥41.360 (1.164 to 1.588)0.00011.452 (1.236 to 1.707)<0.0001
Geographical regionWest1.000 (ref)Ref1.000 (ref)Ref
Middle1.320 (0.982 to 1.775)0.0661.447 (1.079 to 1.940)0.014
East1.383 (1.039 to 1.839)0.0261.125 (0.849 to 1.490)0.412
AreaRural1.000 (ref)Ref1.000 (ref)Ref
Urban0.875 (0.713 to 1.074)0.2010.446 (0.360 to 0.552)<0.0001
Hospital typeSecondary1.000 (ref)Ref1.000 (ref)Ref
Tertiary0.839 (0.662 to 1.064)0.1481.410 (1.140 to 1.743)0.002
P value of interaction for area and hospital type0.0030.037
Variables Consistent OE as reference Centrally reassigned OE Newly diagnosed OE
Adjusted OR (95% CI) P value Adjusted OR (95% CI) P value
Age1.062 (1.022 to 1.102)0.0021.062 (1.016 to 1.109)0.007
Sex0.293 (0.112 to 0.765)0.0120.701 (0.245 to 2.005)0.507
Evaluation of cardiac rhythm
 EKGYes1.702 (0.487 to 5.947)0.40510.173 (2.019 to 51.258)0.005
  • West includes Inner Mongolia, Guangxi, Chongqing, Sichuan,Guizhou, Yunnan, Tibet, Shaanxi, Gansu, Qinghai, Ningxia and Xinjiang. Middle includes Shanxi, Anhui, Jiangxi, Henan, Hubei and Hunan. East includes Beijing, Tianjin, Hebei, Shanghai, Jiangsu, Zhejiang, Fujian,Shandong, Guangdong, Hainan, Liaoning, Jilin and Heilongjian.

  • CE, cardioembolism; LAA, large artery atherosclerosis; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; OE, other determined cause; ref, reference; SVO, small vessel occlusion.