GTN | (n=1996) | P value | No GTN | (n=2004) | P value | |
Headache | Yes | No | Yes | No | ||
No of patients (n) | 360 (18.0) | 1636 (82.0) | 170 (8.5) | 1834 (91.5) | ||
Age (years) | 66.6 (12.4) | 71.1 (11.9) | <0.005 | 67.6 (11.8) | 70.6 (12.2) | 0.002 |
Sex, female (%) | 172 (47.8) | 679 (41.5) | 0.029 | 82 (48.2) | 777 (42.4) | 0.14 |
Pre-morbid mRS score | 0 (1) | 0 (0) | 0.006 | 0 (0) | 0 (1) | 0.12 |
Medical history (%) | ||||||
Hypertension | 220 (61.1) | 1065 (65.1) | 0.15 | 105 (61.8) | 1211 (66) | 0.26 |
Stroke | 51 (14.2) | 262 (16) | 0.38 | 22 (12.9) | 255 (13.9) | 0.73 |
Diabetes mellitus | 52 (14.4) | 289 (17.7) | 0.14 | 29 (17.1) | 324 (17.7) | 0.84 |
Current nitrate use | 18 (5) | 69 (4.2) | 0.51 | 6 (3.5) | 61 (3.3) | 0.89 |
Onset to randomisation (hours) | 25.2 (12.5) | 25.8 (12.9) | 0.42 | 25.1 (12.5) | 26.3 (12.9) | 0.25 |
Haemodynamics | ||||||
Systolic BP (mm Hg) | 166.7 (18.5) | 167.5 (18.8) | 0.46 | 168.4 (19.5) | 167 (19.1) | 0.36 |
Diastolic BP (mm Hg) | 91.6 (12.7) | 89.3 (13) | 0.002 | 89.2 (12.5) | 89.4 (13.4) | 0.88 |
Heart rate, mean (bpm) | 78.2 (14.8) | 77.5 (14.8) | 0.45 | 77.6 (14.3) | 77.3 (14.7) | 0.77 |
Atrial fibrillation (%) | 53 (14.7) | 336 (20.5) | 0.012 | 33 (19.4) | 338 (18.4) | 0.75 |
Syndrome | ||||||
TACS (%) | 86 (23.9) | 527 (32.2) | 0.002 | 58 (34.1) | 535 (29.2) | 0.18 |
LACS (%) | 154 (42.8) | 541 (33.1) | 0.008 | 48 (28.2) | 653 (35.6) | 0.28 |
Dysphasia | 90 (25.0) | 704 (43.0) | <0.005 | 59 (34.7) | 750 (40.9) | 0.12 |
Neglect/inattention | 91 (26.6) | 431 (30) | 0.21 | 61 (40.7) | 485 (29.6) | 0.005 |
Hemianopia | 74 (20.6) | 297 (18.2) | 0.89 | 51 (30) | 313 (17.1) | <0.005 |
SSS score (/58) | 37.2 (11.2) | 33.2 (13.4) | <0.005 | 33.8 (11.9) | 33.5 (13.4) | 0.70 |
Stroke type (%) | ||||||
Ischaemic | 287 (79.7) | 1373 (83.9) | 0.043 | 129 (75.9) | 1544 (84.2) | 0.12 |
Haemorrhage | 39 (10.8) | 278 (17) | 66 (38.8) | 244 (13.3) | ||
Non stroke | 2 (0.6) | 11 (0.7) | 7 (4.1) | 19 (1) | ||
Lesion side (%) | ||||||
Left | 109 (45.0) | 501 (47) | 0.78 | 49 (43) | 541 (45.3) | 0.50 |
Right | 131 (54.1) | 554 (51.9) | 63 (55.3) | 645 (54) | ||
Both | 2 (0.8) | 12 (1.1) | 2 (1.8) | 9 (0.8) | ||
Feeding status, non-oral (%) | 76 (21.1) | 591 (36.1) | <0.005 | 56 (32.9) | 605 (33) | 0.99 |
Neuroimaging adjudication | ||||||
White matter change (%) | 116 (32.2) | 701 (42.8) | <0.005 | 64 (37.6) | 763 (41.6) | 0.16 |
White matter score (/4) | 0 (2) | 0 (2) | <0.005 | 0 (2) | 0 (2) | 0.18 |
Atrophy (%) | 272 (75.6) | 1354 (82.8) | <0.005 | 135 (79.4) | 1464 (79.8) | 0.24 |
Atrophy score (/4) | 2 (1) | 2 (2) | <0.005 | 2 (1) | 2 (2) | 0.007 |
Previous stroke lesion (%) | 194 (53.9) | 992 (60.6) | 0.006 | 81 (47.6) | 1056 (57.6) | 0.002 |
Alteplase | 36 (10.1) | 167 (10.2) | 0.93 | 25 (14.9) | 195 (10.7) | 0.095 |
Continued antihypertensives (%) | 81 (22.5) | 432 (26.4) | 0.009 | 38 (22.4) | 486 (26.5) | 0.26 |
Data are number (%), median (IQR) or mean (SD). Comparison by χ2, Kruskal-Wallis or independent t-test.
BP, blood pressure; GTN, glyceryl trinitrate; LACS, lacunar syndrome; mRS, modified Rankin Scale; SSS, Scandinavian Stroke Scale; TACS, total anterior circulation syndrome.